| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2020-03-31 |
| タイトル |
|
|
タイトル |
Single Nucleotide Polymorphisms and Conserved Transcription Factor Binding Site of CD14 Gene in Yorkshire Terrier |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Canine atopic dermatitis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cloning |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Luciferase reporter assay |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Transcription factor |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ページ属性 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
P(論文) |
| 記事種別 |
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|
内容記述タイプ |
Other |
|
内容記述 |
原著論文 |
| Type |
|
|
内容記述タイプ |
Other |
|
内容記述 |
ORIGINAL ARTICLE |
| 著者 |
Sugino, Haruka
Kawarai, Shinpei
Fujita, Yukihiro
Saito, Miyoko
Kayanuma, Hideki
Fujimori, Yoshihiro
Maruo, Takuya
Madarame, Hiroo
Murakami, Masaru
Kanemaki, Nobuyuki
|
| Author ID |
|
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|
- |
| Author ID |
|
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|
000401 |
| Author ID |
|
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|
000393 |
| Author ID |
|
|
|
000338 |
| Author ID |
|
|
|
000311 |
| Author ID |
|
|
|
- |
| Author ID |
|
|
|
000377 |
| Author ID |
|
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|
000283 |
| Author ID |
|
|
|
000259 |
| Author ID |
|
|
|
000064 |
| Institution or Company |
|
|
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Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University |
| Institution or Company |
|
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Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University |
| Institution or Company |
|
|
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Laboratory of Small Animal Surgery, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University |
| Institution or Company |
|
|
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Laboratory of Small Animal Surgery, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University |
| Institution or Company |
|
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Laboratory of Veterinary Radiology, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University |
| Institution or Company |
|
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Fujimori Animal General Hospital |
| Institution or Company |
|
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Laboratory of Veterinary Radiology, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University |
| Institution or Company |
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|
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Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University |
| Institution or Company |
|
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Laboratory of Molecular Biology, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University |
| Institution or Company |
|
|
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Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University |
| Abstract |
|
|
内容記述タイプ |
Other |
|
内容記述 |
In humans, single nucleotide polymorphisms (SNPs) of CD14 promoter region are associated with allergic diseases. There are no reports of canine CD14 gene cloning, nor any reports studying the pathogenesis of CD14 polymorphism in dogs. In this study, canine CD14 gene was cloned by 5' and 3' RACE method and its SNPs were analyzed. The presence of two SNPs were identified. SNP1 was located at predicted AP-1 binding site of CD14 promoter region (-187C>T) in the Yorkshire terrier. SNP2 (c.930G>A), silent mutation of Glu, identified in 5 dog breeds. The relative transcriptional activity of a general breed type CD14 promoter (-187C/luc) did not differ from those of Yorkshire terrier type (-187T/luc); however, the relative activity was diminished when the AP-1 site was mutated. In conclusion, CD14 gene structure was highly conserved in dog breeds and its expression could be regulated by the transcription factor AP-1. |
| 書誌情報 |
麻布大学雑誌
en : Journal of Azabu University
巻 31,
p. 1-10,
発行日 2020-03-31
|
| 出版者 |
|
|
出版者 |
麻布大学 |
| Publisher |
|
|
出版者 |
Azabu University |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1346-5880 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11561468 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| text version |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
bull_jau_vol31-001.pdf (1.4 MB)
