{"created":"2023-06-19T07:19:19.344254+00:00","id":5357,"links":{},"metadata":{"_buckets":{"deposit":"4b8f5d8e-2e19-4f56-b3ac-5d85ea2d5ed6"},"_deposit":{"created_by":4,"id":"5357","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"5357"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00005357","sets":["17:234:241","17:253:331","17:38:260","17:38:261","17:38:268","17:40:280","17:40:289","17:40:290","31:181:533"]},"author_link":["23031","23034","23035","23032","23039","23037","23038","23033","23040","23036"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"In humans, single nucleotide polymorphisms (SNPs) of CD14 promoter region are associated with allergic diseases. There are no reports of canine CD14 gene cloning, nor any reports studying the pathogenesis of CD14 polymorphism in dogs. In this study, canine CD14 gene was cloned by 5' and 3' RACE method and its SNPs were analyzed. The presence of two SNPs were identified. SNP1 was located at predicted AP-1 binding site of CD14 promoter region (-187C>T) in the Yorkshire terrier. SNP2 (c.930G>A), silent mutation of Glu, identified in 5 dog breeds. The relative transcriptional activity of a general breed type CD14 promoter (-187C/luc) did not differ from those of Yorkshire terrier type (-187T/luc); however, the relative activity was diminished when the AP-1 site was mutated. In conclusion, CD14 gene structure was highly conserved in dog breeds and its expression could be regulated by the transcription factor AP-1.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"ORIGINAL ARTICLE","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"-"},{"subitem_text_value":"000401"},{"subitem_text_value":"000393"},{"subitem_text_value":"000338"},{"subitem_text_value":"000311"},{"subitem_text_value":"-"},{"subitem_text_value":"000377"},{"subitem_text_value":"000283"},{"subitem_text_value":"000259"},{"subitem_text_value":"000064"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University"},{"subitem_text_value":"Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University"},{"subitem_text_value":" Laboratory of Small Animal Surgery, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Laboratory of Small Animal Surgery, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Laboratory of Veterinary Radiology, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Fujimori Animal General Hospital"},{"subitem_text_value":"Laboratory of Veterinary Radiology, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University"},{"subitem_text_value":"Laboratory of Molecular Biology, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sugino, Haruka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawarai, Shinpei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Yukihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Miyoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kayanuma, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimori, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maruo, Takuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Madarame, Hiroo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanemaki, Nobuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-27"}],"displaytype":"detail","filename":"bull_jau_vol31-001.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol31-001.pdf","url":"https://az.repo.nii.ac.jp/record/5357/files/bull_jau_vol31-001.pdf"},"version_id":"ce6e9856-3f57-4a12-9f80-d5563240a6de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Canine atopic dermatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cloning","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Luciferase reporter assay","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transcription factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Single Nucleotide Polymorphisms and Conserved Transcription Factor Binding Site of CD14 Gene in Yorkshire Terrier","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Single Nucleotide Polymorphisms and Conserved Transcription Factor Binding Site of CD14 Gene in Yorkshire Terrier","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["241","260","261","268","280","289","290","331","533"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-31"},"publish_date":"2020-03-31","publish_status":"0","recid":"5357","relation_version_is_last":true,"title":["Single Nucleotide Polymorphisms and Conserved Transcription Factor Binding Site of CD14 Gene in Yorkshire Terrier"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:40:31.338417+00:00"}