@article{oai:az.repo.nii.ac.jp:00005357,
 author = {Sugino, Haruka and Kawarai, Shinpei and Fujita, Yukihiro and Saito, Miyoko and Kayanuma, Hideki and Fujimori, Yoshihiro and Maruo, Takuya and Madarame, Hiroo and Murakami, Masaru and Kanemaki, Nobuyuki},
 journal = {麻布大学雑誌, Journal of Azabu University},
 month = {Mar},
 note = {In humans, single nucleotide polymorphisms (SNPs) of CD14 promoter region are associated with allergic diseases. There are no reports of canine CD14 gene cloning, nor any reports studying the pathogenesis of CD14 polymorphism in dogs. In this study, canine CD14 gene was cloned by 5' and 3' RACE method and its SNPs were analyzed. The presence of two SNPs were identified. SNP1 was located at predicted AP-1 binding site of CD14 promoter region (-187C>T) in the Yorkshire terrier. SNP2 (c.930G>A), silent mutation of Glu, identified in 5 dog breeds. The relative transcriptional activity of a general breed type CD14 promoter (-187C/luc) did not differ from those of Yorkshire terrier type (-187T/luc); however, the relative activity was diminished when the AP-1 site was mutated. In conclusion, CD14 gene structure was highly conserved in dog breeds and its expression could be regulated by the transcription factor AP-1., P(論文), 原著論文, application/pdf, ORIGINAL ARTICLE},
 pages = {1--10},
 title = {Single Nucleotide Polymorphisms and Conserved Transcription Factor Binding Site of CD14 Gene in Yorkshire Terrier},
 volume = {31},
 year = {2020}
}