| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2014-02-21 |
| タイトル |
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タイトル |
初乳抗体の腸管内での作用に関する研究 |
| タイトル |
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タイトル |
Bovine immune colostral antibody against verotoxin 2 derived from Escherichia coli O157:H7-resistance to proteases and effects on verotoxin 2 in small intestine of beagle dogs |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
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内容記述タイプ |
Other |
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内容記述 |
P(論文) |
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内容記述タイプ |
Other |
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内容記述 |
特集 |
| Type |
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内容記述タイプ |
Other |
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内容記述 |
FEATURE ARTICLES |
| 著者 |
山本, 静雄
栗林, 尚志
清田, 哲郎
福山, 正文
古畑, 勝則
Yamamoto, Shizuo
Kuribayashi, Takashi
Seita, Tetsuro
Furuhata, Katsunori
Fukuyama, Masafumi
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000117 |
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000345 |
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- |
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000119 |
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000279 |
| Author ID |
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000117 |
| Author ID |
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000345 |
| Author ID |
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- |
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000119 |
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000279 |
| 所属機関 |
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麻布大学生命・環境科学部免疫学研究室 |
| 所属機関 |
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麻布大学生命・環境科学部免疫学研究室 |
| 所属機関 |
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麻布大学生命・環境科学部免疫学研究室 |
| 所属機関 |
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麻布大学生命・環境科学部微生物学研究室 |
| 所属機関 |
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麻布大学生命・環境科学部微生物学研究室 |
| Institution or Company |
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Laboratories of Immunology, School of Life and Environmental Science, Azabu University |
| Institution or Company |
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Laboratories of Immunology, School of Life and Environmental Science, Azabu University |
| Institution or Company |
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Laboratories of Immunology, School of Life and Environmental Science, Azabu University |
| Institution or Company |
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Laboratories of Microbiology, School of Life and Environmental Science, Azabu University |
| Institution or Company |
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Laboratories of Microbiology, School of Life and Environmental Science, Azabu University |
| Abstract |
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内容記述タイプ |
Other |
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内容記述 |
Resistance to intestinal proteases and efficacy against verotoxin (VT) 2 of a colostral antibody administered orally via catheter were investigated in beagle dogs. Bovine colostral antibody remained in the small intestine for 2 hours, whereas little serum antibody remained at 1.5 hours after administration. The bovine colostral antibody was not inactivated by proteases in the small intestine. Furthermore, the antibody activity of S-IgA did not change until 2 hours after administration; however, the activity of IgG and IgM antibodies decreased by two-thirds and two-fifths at 2 hours after administration, respectively.
Seven beagle dogs inoculated with Escherichia coli (E. coli) O157:H7 producing VT2 were administered bovine colostral antibody or bovine colostral whey without antibody. With administration of bovine colostral whey without antibody, the amount of VT2 in feces decreased gradually after administration and increased again at 5 days after inoculation, while bovine colostral antibody significantly reduced the amount of VT2 in feces the day after administration. In addition, 9 beagle dogs were administered bovine colostral antibody, bovine plasma antibody or saline. The amount of VT2 in feces also significantly reduced rapidly after administration of bovine colostral antibody than administration of bovine plasma antibody or saline. |
| 書誌情報 |
麻布大学雑誌
en : Journal of Azabu University
巻 17/18,
p. 202-210,
発行日 2009-03-31
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| 出版者 |
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出版者 |
麻布大学 |
| Publisher |
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出版者 |
Azabu University |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-5880 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11561468 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| text version |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
bull_jau_vol17-18-202 (669.3 kB)
