@article{oai:az.repo.nii.ac.jp:00003922,
 author = {山本, 静雄 and 栗林, 尚志 and 清田, 哲郎 and 福山, 正文 and 古畑, 勝則 and Yamamoto, Shizuo and Kuribayashi, Takashi and Seita, Tetsuro and Furuhata, Katsunori and Fukuyama, Masafumi},
 journal = {麻布大学雑誌, Journal of Azabu University},
 month = {Mar},
 note = {Resistance to intestinal proteases and efficacy against verotoxin (VT) 2 of a colostral antibody administered orally via catheter were investigated in beagle dogs. Bovine colostral antibody remained in the small intestine for 2 hours, whereas little serum antibody remained at 1.5 hours after administration. The bovine colostral antibody was not inactivated by proteases in the small intestine. Furthermore, the antibody activity of S-IgA did not change until 2 hours after administration; however, the activity of IgG and IgM antibodies decreased by two-thirds and two-fifths at 2 hours after administration, respectively.
 Seven beagle dogs inoculated with Escherichia coli (E. coli) O157:H7 producing VT2 were administered bovine colostral antibody or bovine colostral whey without antibody. With administration of bovine colostral whey without antibody, the amount of VT2 in feces decreased gradually after administration and increased again at 5 days after inoculation, while bovine colostral antibody significantly reduced the amount of VT2 in feces the day after administration. In addition, 9 beagle dogs were administered bovine colostral antibody, bovine plasma antibody or saline. The amount of VT2 in feces also significantly reduced rapidly after administration of bovine colostral antibody than administration of bovine plasma antibody or saline., P(論文), 特集, application/pdf, FEATURE ARTICLES},
 pages = {202--210},
 title = {初乳抗体の腸管内での作用に関する研究},
 volume = {17/18},
 year = {2009}
}