| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2014-03-20 |
| タイトル |
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タイトル |
Association of paraoxonase 1 gene polymorphism with Intima-Media Thickness (IMT) of the carotid arteries in japanese type 2 diabetic patients |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
paraoxonase 1 |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
genetic polymorphism |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
intima-media thickness (IMT) |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| ID登録 |
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ID登録 |
10.14944/00003716 |
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ID登録タイプ |
JaLC |
| ページ属性 |
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内容記述タイプ |
Other |
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内容記述 |
P(論文) |
| 記事種別 |
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内容記述タイプ |
Other |
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内容記述 |
原著論文 |
| Type |
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内容記述タイプ |
Other |
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内容記述 |
ORIGINAL ARTICLE |
| 著者 |
Honda, Teruko
Takada, Kayoko
Maeda, Makiko
Nonen, Sinpei
Motomura, Takashi
Maeda, Keiji
Fujio, Yasushi
Azuma, Junichi
Yamamoto, Isamu \n
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| Author ID |
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000383 |
| Author ID |
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000386 |
| Author ID |
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- |
| Author ID |
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| Author ID |
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| Author ID |
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- |
| Author ID |
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- |
| Author ID |
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- |
| Author ID |
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000380 |
| Institution or Company |
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School of Life and Environmental Science, Azabu University |
| Institution or Company |
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School of Life and Environmental Science, Azabu University |
| Institution or Company |
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Faculty of Pharmacy, Hyogo University of Health Sciences |
| Institution or Company |
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Faculty of Pharmacy, Hyogo University of Health Sciences |
| Institution or Company |
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Department of Internal Medicine, NTT West Osaka Hospital |
| Institution or Company |
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Department of Internal Medicine, NTT West Osaka Hospital |
| Institution or Company |
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Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Scienes, Osaka University |
| Institution or Company |
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Faculty of Pharmacy, Hyogo University of Health Sciences |
| Institution or Company |
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School of Life and Environmental Science, Azabu University |
| Abstract |
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内容記述タイプ |
Other |
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内容記述 |
Purpose: We investigated the association between paraoxonase 1 (PON1)-192 genotypes and intimamedia thickness (IMT) of carotid arteries in diabetic patients.
Methods: One hundred and fifty-five Japanese type 2 diabetic patients aged from 40 to 79 years were enrolled in this study. Genotypes of the patients were determined using the PCR-RFLP method. The IMT of carotid arteries of the subjects was measured by ultrasound imaging.
Results: The PON1 genotypes frequencies were as follows: 18QQ (0.116), 70QR (0.452) and 67RR (0.432). IMT values of the RR group were significantly greater (1.08±0.41 mm, n=67) than those of the Q group, which consisted of patients carrying one or two Q alleles (0.95±0.27 mm, n=88, P=0.023). There were no significant difference in the clinical characteristics between the two groups.
Conclusion: The results indicate that the PON1-192RR genotype is associated with intima media thickening of the carotid arteries in diabetic patients. |
| 書誌情報 |
麻布大学雑誌
en : Journal of Azabu University
巻 24,
p. 31-35,
発行日 2013-01-31
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| 出版者 |
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出版者 |
麻布大学 |
| Publisher |
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出版者 |
Azabu University |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-5880 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11561468 |
| NII論文ID(NAID) |
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内容記述タイプ |
Other |
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内容記述 |
40019736749 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| text version |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
bull_jau_vol24-031 (476.6 kB)
