@article{oai:az.repo.nii.ac.jp:00003737,
 author = {Honda, Teruko and Takada, Kayoko and Maeda, Makiko and Nonen, Sinpei and Motomura, Takashi and Maeda, Keiji and Fujio, Yasushi and Azuma, Junichi and Yamamoto, Isamu \n},
 journal = {麻布大学雑誌, Journal of Azabu University},
 month = {Jan},
 note = {Purpose: We investigated the association between paraoxonase 1 (PON1)-192 genotypes and intimamedia thickness (IMT) of carotid arteries in diabetic patients.
 Methods: One hundred and fifty-five Japanese type 2 diabetic patients aged from 40 to 79 years were enrolled in this study. Genotypes of the patients were determined using the PCR-RFLP method. The IMT of carotid arteries of the subjects was measured by ultrasound imaging.
 Results: The PON1 genotypes frequencies were as follows: 18QQ (0.116), 70QR (0.452) and 67RR (0.432). IMT values of the RR group were significantly greater (1.08±0.41 mm, n=67) than those of the Q group, which consisted of patients carrying one or two Q alleles (0.95±0.27 mm, n=88, P=0.023). There were no significant difference in the clinical characteristics between the two groups.
 Conclusion: The results indicate that the PON1-192RR genotype is associated with intima media thickening of the carotid arteries in diabetic patients., P(論文), 40019736749, 原著論文, application/pdf, ORIGINAL ARTICLE},
 pages = {31--35},
 title = {Association of paraoxonase 1 gene polymorphism with Intima-Media Thickness (IMT) of the carotid arteries in japanese type 2 diabetic patients},
 volume = {24},
 year = {2013}
}