{"_buckets": {"deposit": "12222460-4b92-4eb9-87d7-be3d2326c412"}, "_deposit": {"created_by": 4, "id": "5056", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "5056"}, "status": "published"}, "_oai": {"id": "oai:az.repo.nii.ac.jp:00005056", "sets": ["217", "278", "353", "355", "494"]}, "author_link": ["21939", "21936", "21941", "21937", "21935", "21934", "21940", "21938"], "item_12_biblio_info_16": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-03-31", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "228", "bibliographicPageStart": "224", "bibliographicVolumeNumber": "15/16", "bibliographic_titles": [{"bibliographic_title": "麻布大学雑誌"}, {"bibliographic_title": "Journal of Azabu University", "bibliographic_titleLang": "en"}]}]}, "item_12_description_13": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "我々は,セロトニン受容体のような神経伝達物質受容体あるいはそのトランスポーター(例えばセロトニン・トランスポーター(5-HTT))の遺伝子多型とオランザピンのような非定型抗精神病薬との関係を調査した。その結果,5-HTTのs対立遺伝子をもつ患者ともたない患者との間で,統合失調症陰性症状に対するオランザピンの効果に,統計学的な有意差が見られた。一方,アルツハイマー病患者に認められる精神神経症状に関わる5HT2A受容体と神経機能に重要な役割を持つダウの関係を明らかにするための予備段階として,2つのダウ・アイソフォーム(T3RとT4R)を明確に識別できる特性の高いポリクローン抗体を作製した。これらの抗体を用いて5HT2A受容体とタウとの関係を明らかにするために免疫組織化学的解析等を進める予定である。", "subitem_description_type": "Abstract"}]}, "item_12_description_14": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "We investigated the relationships between the effects of atypical antipsychotics such as olanzapine and neurotransmitter receptor and transporter gene polymorphisms such as serotonin receptor and transporter (5-HTT). There was a significant difference in the effect of olanzapine on the schizophrenia negative syndrome among the patients with and without the s allele of 5-HTT. Two types of tau isoform are found in neurofibrillary tangles-a pathological hallmark of tauopathies. To study how and which tau isoforms contribute to neurobal degeneration, we have developed two novel conformation-sensitive antibodies. There was no cross-reactivity between T3R (tau isoform, three-repeat tau) and T4R (four-repeat tau), and T3R and T4R showed reduced binding to the thioflavin-positive β-structural form of their target.", "subitem_description_type": "Other"}]}, "item_12_description_2": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_12_description_3": {"attribute_name": "記事種別", "attribute_value_mlt": [{"subitem_description": "特集", "subitem_description_type": "Other"}]}, "item_12_description_34": {"attribute_name": "format", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_12_description_4": {"attribute_name": "Type", "attribute_value_mlt": [{"subitem_description": "FEATURE ARTICLES", "subitem_description_type": "Other"}]}, "item_12_publisher_19": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "麻布大学"}]}, "item_12_publisher_20": 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"Neurophysiology, Molecular Biology and Immunology, Course of Environmental Health Science, Graduate school, Azabu University"}, {"subitem_text_value": "Neurophysiology, Molecular Biology and Immunology, Course of Environmental Health Science, Graduate school, Azabu University"}, {"subitem_text_value": "Neurophysiology, Molecular Biology and Immunology, Course of Environmental Health Science, Graduate school, Azabu University"}, {"subitem_text_value": "Neurophysiology, Molecular Biology and Immunology, Course of Environmental Health Science, Graduate school, Azabu University"}]}, "item_12_text_9": {"attribute_name": "著者ID", "attribute_value_mlt": [{"subitem_text_value": "000278"}, {"subitem_text_value": "000126 "}, {"subitem_text_value": "000298"}, {"subitem_text_value": "000117"}]}, "item_12_version_type_29": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, 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