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  1. 著者
  2. T
  3. 髙木 敬彦
  1. 著者
  2. W
  3. 和久井 信
  1. 紀要
  2. 麻布大学雑誌
  3. 麻布大学雑誌Vol.9/10 (2004)

発がん性物質暴露に対する肝細胞の初期反応に関する毒性病理学的検討

https://az.repo.nii.ac.jp/records/4673
https://az.repo.nii.ac.jp/records/4673
e0b37cfe-9926-4aa0-b100-04861c0cd5d6
名前 / ファイル ライセンス アクション
bull_jau_vol9-10-170.pdf bull_jau_vol9-10-170.pdf (158.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2004-01-01
タイトル
タイトル 発がん性物質暴露に対する肝細胞の初期反応に関する毒性病理学的検討
タイトル
言語 en
タイトル Initial changes of rat liver following exposure to 7, 12-dimethylbenz [a] anthracene
言語
言語 jpn
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
ページ属性
内容記述タイプ Other
内容記述 P(論文)
記事種別
内容記述タイプ Other
内容記述 特集
Type
内容記述タイプ Other
内容記述 FEATURE ARTICLES
著者 和久井, 信

× 和久井, 信

WEKO 20313

和久井, 信

ja-Kana ワクイ, シン

Search repository
高木, 敬彦

× 高木, 敬彦

WEKO 20314

高木, 敬彦

ja-Kana タカギ, ユキヒコ

Search repository
内藤, 博之

× 内藤, 博之

WEKO 20315

内藤, 博之

ja-Kana ナイトウ, ヒロユキ

Search repository
Wakui, Shin

× Wakui, Shin

WEKO 20316

en Wakui, Shin

Search repository
Takagi, Yukihiko

× Takagi, Yukihiko

WEKO 20317

en Takagi, Yukihiko

Search repository
Naito, Hiroyuki

× Naito, Hiroyuki

WEKO 20318

en Naito, Hiroyuki

Search repository
著者ID
000073
著者ID
000068
著者ID
-
Author ID
000073
Author ID
000068
Author ID
-
所属機関
麻布大学大学院獣医学研究科
所属機関
麻布大学大学院獣医学研究科
所属機関
麻布大学大学院獣医学研究科
Institution or Company
Graduate School of Veterinary Science, Azabu University
Institution or Company
Graduate School of Veterinary Science, Azabu University
Institution or Company
Graduate School of Veterinary Science, Azabu University
抄録
内容記述タイプ Abstract
内容記述 Procarcinogenである7,12-dimethbenz [a] anthracene(DMBA)暴露後のラット肝細胞の経時的変化に関して超微形態学的・生化学的に検討した。DMBA投与後に一過性のglycogen phosphorylase aの発現低下から,一過性のglycogen顆粒貯留が認められた。しかし,投与後2日にCYP1の発現と肝細胞での解糖系亢進が認められたことから,同時期にDMBAのultimate carcinogenへの代謝が進行することが示唆された。
Abstract
内容記述タイプ Other
内容記述 The initial changes in rat liver after a single oral dose of 7,12-dimethylbenz[a] anthracene (DMBA) (100mg/kg b.w.) were ultrastructually investigated. Glycogen granules of centrilobular hepatocytes increased with time to peak on Day 1. After this, they sharply decreased on Day 2, and on Days 5-10 returned to levels similar to those of the vehicle group (corn oil). On Day 2, the size of the centrilobular hepatocytes was decreased significantly, and the nuclear to cytoplasmic ratio was increased significantly. While the activity of hepatic glycogen phosphorylase a was decreased at 6-12 hrs and on Day 1, on Days 2-10, it was elevated to a level similar to that of the vehicle group. Thus, the initial temporary storage of hepatic glycogen granules following DMBA administration involved the inhibition of glycogenolysis in centrilobular hepatocytes. Glycogen granules appeared in restricted regions near the smooth endoplasmic reticulum (sER). Following DMBA administration, proliferation of sER of the centrilobular hepatocytes also gradually increased with time to peak on Day 2, after which it decreased, and on Days 5-10 returned to a level similar to that of the vehicle group. Results from the present study indicate that exposure of rats to DMBA could induce a reversible initial change in the hepatic glycogen metabolism.
書誌情報 麻布大学雑誌
en : Journal of Azabu University

巻 9/10, p. 170-171, 発行日 2005-03-31
出版者
出版者 麻布大学
Publisher
出版者 Azabu University
ISSN
収録物識別子タイプ ISSN
収録物識別子 1346-5880
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11561468
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
text version
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
format
内容記述タイプ Other
内容記述 application/pdf
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