@article{oai:az.repo.nii.ac.jp:00004673,
 author = {和久井, 信 and 高木, 敬彦 and 内藤, 博之 and Wakui, Shin and Takagi, Yukihiko and Naito, Hiroyuki},
 journal = {麻布大学雑誌, Journal of Azabu University},
 month = {Mar},
 note = {Procarcinogenである7,12-dimethbenz [a] anthracene(DMBA)暴露後のラット肝細胞の経時的変化に関して超微形態学的・生化学的に検討した。DMBA投与後に一過性のglycogen phosphorylase aの発現低下から,一過性のglycogen顆粒貯留が認められた。しかし,投与後2日にCYP1の発現と肝細胞での解糖系亢進が認められたことから,同時期にDMBAのultimate carcinogenへの代謝が進行することが示唆された。, The initial changes in rat liver after a single oral dose of 7,12-dimethylbenz[a] anthracene (DMBA) (100mg/kg b.w.) were ultrastructually investigated. Glycogen granules of centrilobular hepatocytes increased with time to peak on Day 1. After this, they sharply decreased on Day 2, and on Days 5-10 returned to levels similar to those of the vehicle group (corn oil). On Day 2, the size of the centrilobular hepatocytes was decreased significantly, and the nuclear to cytoplasmic ratio was increased significantly. While the activity of hepatic glycogen phosphorylase a was decreased at 6-12 hrs and on Day 1, on Days 2-10, it was elevated to a level similar to that of the vehicle group. Thus, the initial temporary storage of hepatic glycogen granules following DMBA administration involved the inhibition of glycogenolysis in centrilobular hepatocytes. Glycogen granules appeared in restricted regions near the smooth endoplasmic reticulum (sER). Following DMBA administration, proliferation of sER of the centrilobular hepatocytes also gradually increased with time to peak on Day 2, after which it decreased, and on Days 5-10 returned to a level similar to that of the vehicle group. Results from the present study indicate that exposure of rats to DMBA could induce a reversible initial change in the hepatic glycogen metabolism., P(論文), 特集, application/pdf, FEATURE ARTICLES},
 pages = {170--171},
 title = {発がん性物質暴露に対する肝細胞の初期反応に関する毒性病理学的検討},
 volume = {9/10},
 year = {2005},
 yomi = {ワクイ, シン and タカギ, ユキヒコ and ナイトウ, ヒロユキ}
}