| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2002-01-01 |
| タイトル |
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タイトル |
精神疾患関連遺伝子多型の解析 |
| タイトル |
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タイトル |
Analysis of polymorphism in genes related to psychiatric diseases |
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言語 |
en |
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言語 |
jpn |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
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内容記述タイプ |
Other |
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内容記述 |
P(論文) |
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内容記述タイプ |
Other |
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内容記述 |
特集 |
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Other |
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FEATURE ARTICLES |
| 著者 |
松田, 基夫
岩橋, 和彦
信田, 卓夫
小方, 宗次
吉原, 英児
荻原, 喜久美
陰山, 敏昭
柏崎, 直巳
村山, 洋
飴野, 清
高島, 明彦
Matsuda, Motoo
Iwahashi, Kazuhiko
Sida, Takuo
Ogata, Munetsugu
Yoshiwara, Eiji
Ogihara, Kikumi
Kageyama, Toshiaki
Kashiwazaki, Naomi
Murayama, Ohoshi
Ameno, Kiyoshi
Takashima, Akihiko
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000135 |
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000278 |
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000375 |
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- |
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000126 |
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000127 |
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000274 |
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000298 |
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000126 |
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| 所属機関 |
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麻布大学環境保健学部 |
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麻布大学環境保健学部 |
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麻布大学獣医学部 |
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麻布大学獣医学部 |
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麻布大学環境保健学部 |
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麻布大学環境保健学部 |
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麻布大学獣医学部 |
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麻布大学獣医学部 |
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麻布大学環境保健学部 |
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香川医科大学医学部 |
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理化学研究所脳科学総合研究センター |
| Institution or Company |
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School of Environmental Health Sciences, Azabu University |
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School of Environmental Health Sciences, Azabu University |
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School of Veterinary Medicine, Azabu University |
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School of Veterinary Medicine, Azabu University |
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School of Environmental Health Sciences, Azabu University |
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School of Environmental Health Sciences, Azabu University |
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School of Veterinary Medicine, Azabu University |
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School of Veterinary Medicine, Azabu University |
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School of Environmental Health Sciences, Azabu University |
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School of Medicine, Kagawa Medical University |
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Brain Science Institute, RIKEN |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
ヒトGSK3β遺伝子のプロモーター領域について多型解析を行った結果,日本人特有と考えられる新規-塩基遺伝子多型を含む遺伝子多型を固定した。また,マウス,ラット,ウシ,イヌ及びブタとの比較解析から転写開始点から翻訳開始点にかけて多様性に富む領域であることが明らかとなった。これらの結果はGSK3β遺伝子発現調節の詳細な解析を進める上で重要な結果であると考えている。 |
| Abstract |
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内容記述タイプ |
Other |
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内容記述 |
The aim of this study is to reveal polymorphism in genes associated with psychiatric disorders and/or neurodegenerative diseases. Using genomic DNA of 44 normal young adults, nucleotide sequences of the 5' region of GSK3/3 gene containing the promoter region was analyzed. Polymorphic nucleotides were identified at nucleotide position, -717 (T/C), -338 (G/C), -252 (G/T), -180 (A/T), -50 (T/C), +457 (C/G) and +471(C/A). Some of them were demonstrated to be novel polymorphism and may be specific to the Japanese. Compared with other mammalian animals such as mouse, rat, bovine, dog and pig, the region between the transcription initiation site and the initiation codon was revealed to be highly varied. However sequences of the other region analyzed were highly conserved.
Lithium, a therapeutic agent for psychiatric disorder such as bipolar, inhibits GSK3/3 and production of amyloid/3, a main component of senile plaques in Alzheimer's disease. In addition, the level of GSK/3 is decreased in schizophrenia patients and increased depending on age. In conclusion, considering these facts, the present data may provide us basic and important information in order to study mechanism (s) by which GSK3β Gene expression is regulated. |
| 書誌情報 |
麻布大学雑誌
en : Journal of Azabu University
巻 5/6,
p. 199-201,
発行日 2003-03-31
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| 出版者 |
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出版者 |
麻布大学 |
| Publisher |
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出版者 |
Azabu University |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-5880 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11561468 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| text version |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
bull_jau_vol5-6-199.pdf (252.6 kB)
