{"created":"2023-06-19T07:18:50.523740+00:00","id":4451,"links":{},"metadata":{"_buckets":{"deposit":"ad4ac864-2764-4701-85a9-a6a99a2f6421"},"_deposit":{"created_by":4,"id":"4451","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4451"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004451","sets":["17:251:307","17:253:322","17:257:353","17:37:217","17:38:265","17:40:278","17:40:287","31:181:487"]},"author_link":["19478","19482","19471","19485","19484","19467","19481","19488","19486","19480","19487","19469","19479","19472","19473","19474","19476","19477","19468","19470","19483","19475"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"201","bibliographicPageStart":"199","bibliographicVolumeNumber":"5/6","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトGSK3β遺伝子のプロモーター領域について多型解析を行った結果,日本人特有と考えられる新規-塩基遺伝子多型を含む遺伝子多型を固定した。また,マウス,ラット,ウシ,イヌ及びブタとの比較解析から転写開始点から翻訳開始点にかけて多様性に富む領域であることが明らかとなった。これらの結果はGSK3β遺伝子発現調節の詳細な解析を進める上で重要な結果であると考えている。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The aim of this study is to reveal polymorphism in genes associated with psychiatric disorders and/or neurodegenerative diseases. Using genomic DNA of 44 normal young adults, nucleotide sequences of the 5' region of GSK3/3 gene containing the promoter region was analyzed. Polymorphic nucleotides were identified at nucleotide position, -717 (T/C), -338 (G/C), -252 (G/T), -180 (A/T), -50 (T/C), +457 (C/G) and +471(C/A). Some of them were demonstrated to be novel polymorphism and may be specific to the Japanese. Compared with other mammalian animals such as mouse, rat, bovine, dog and pig, the region between the transcription initiation site and the initiation codon was revealed to be highly varied. However sequences of the other region analyzed were highly conserved.\nLithium, a therapeutic agent for psychiatric disorder such as bipolar, inhibits GSK3/3 and production of amyloid/3, a main component of senile plaques in Alzheimer's disease. In addition, the level of GSK/3 is decreased in schizophrenia patients and increased depending on age. In conclusion, considering these facts, the present data may provide us basic and important information in order to study mechanism (s) by which GSK3β Gene expression is regulated.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE 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Veterinary Medicine, Azabu University"},{"subitem_text_value":"School of Environmental Health Sciences, Azabu University"},{"subitem_text_value":"School of Environmental Health Sciences, Azabu University"},{"subitem_text_value":"School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"School of Environmental Health Sciences, Azabu University"},{"subitem_text_value":"School of Medicine, Kagawa Medical University"},{"subitem_text_value":"Brain Science Institute, RIKEN"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000135"},{"subitem_text_value":"000278"},{"subitem_text_value":"000375"},{"subitem_text_value":"-"},{"subitem_text_value":"000126 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英児"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"荻原, 喜久美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"陰山, 敏昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柏崎, 直巳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村山, 洋"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"飴野, 清"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高島, 明彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Motoo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwahashi, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sida, Takuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogata, Munetsugu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshiwara, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogihara, Kikumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kageyama, Toshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kashiwazaki, Naomi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murayama, Ohoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ameno, Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takashima, Akihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2002-01-01"}],"displaytype":"detail","filename":"bull_jau_vol5-6-199.pdf","filesize":[{"value":"252.6 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