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肝臓におけるNO産生とその調節機構の解析
https://az.repo.nii.ac.jp/records/3927
https://az.repo.nii.ac.jp/records/3927a32dde11-2848-4e0c-aa9f-a278297c5e04
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bull_jau_vol17-18-231 (170.6 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-02-21 | |||||||||
| タイトル | ||||||||||
| タイトル | 肝臓におけるNO産生とその調節機構の解析 | |||||||||
| タイトル | ||||||||||
| タイトル | Developmental changes of NO production in neonata rat liver | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| ページ属性 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | P(論文) | |||||||||
| 記事種別 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 特集 | |||||||||
| Type | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | FEATURE ARTICLES | |||||||||
| 著者 |
滝沢, 達也
× 滝沢, 達也
× Takizawa, Tatsuya
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| 著者ID | ||||||||||
| 000244 | ||||||||||
| Author ID | ||||||||||
| 000244 | ||||||||||
| 所属機関 | ||||||||||
| 麻布大学大学院獣医学研究科 | ||||||||||
| Institution or Company | ||||||||||
| Graduate School of Veterinary Medicine, Azabu University | ||||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | 生後3週齢のラット新生子の肝臓においてNO産生の亢進が認められ，このNO産生はeNOS Ser^1176のリン酸化により調節され，産生されたNOは肝細胞の増殖を維持していることが示唆された。 | |||||||||
| Abstract | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Hepatocytes have high ability to proliferate and are still undifferentiated in neonates. During development, the rat liver at 3 weeks after birth has been reported as the late maturation stage, increasing the number of the differentiated hepatocytes. Nitric oxide (NO) has been reported as a key mediator to enhance the hepatocyte proliferation in regenerating liver. However it is unclear that whether NO contributes to the hepatocyte proliferation in neonatal rat. We performed a semi-quantitative evaluation of endogenous NO production using a spin trap followed by electron paramagnetic resonance (EPR) spectroscopy with Fe-N, N-diethyldithiocarbamate (Fe-DETC) complex as a NO-trapping reagent in the rat liver during development. The NO production in the liver was increased at 3 weeks after birth and then declined. Administration of the NO synthase (NOS) inhibitor L-NAME suppressed the endogenous NO production and the hepatocyte proliferation in the rat liver at 3 weeks after birth. The phosphorylation level of NOS3 at Ser1177, the activating residue of the enzyme, was increased at 3 weeks after birth and then declined as well as the NO production pattern. These results suggest that NO is mainly synthesized by NOS3 up-regulated by phosphorylation at Ser1177 and enhances the hepatocyte proliferation in the rat liver at 3 weeks after birth. These findings provide a novel insight into the contribution of NO to hepatic growth and the liver maturation during development. | |||||||||
| 書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 17/18, p. 231-233, 発行日 2009-03-31 |
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| 出版者 | ||||||||||
| 出版者 | 麻布大学 | |||||||||
| Publisher | ||||||||||
| 出版者 | Azabu University | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1346-5880 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11561468 | |||||||||
| NII論文ID(NAID) | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 40016759596 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| text version | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| format | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
