{"created":"2023-06-19T07:18:32.397783+00:00","id":3927,"links":{},"metadata":{"_buckets":{"deposit":"47111e2f-33bc-426e-9a19-31a3646d9605"},"_deposit":{"created_by":4,"id":"3927","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3927"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00003927","sets":["17:254:339","31:181:468"]},"author_link":["18057","18056"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"233","bibliographicPageStart":"231","bibliographicVolumeNumber":"17/18","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生後3週齢のラット新生子の肝臓においてNO産生の亢進が認められ，このNO産生はeNOS Ser^1176のリン酸化により調節され，産生されたNOは肝細胞の増殖を維持していることが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Hepatocytes have high ability to proliferate and are still undifferentiated in neonates. During development, the rat liver at 3 weeks after birth has been reported as the late maturation stage, increasing the number of the differentiated hepatocytes. Nitric oxide (NO) has been reported as a key mediator to enhance the hepatocyte proliferation in regenerating liver. However it is unclear that whether NO contributes to the hepatocyte proliferation in neonatal rat. We performed a semi-quantitative evaluation of endogenous NO production using a spin trap followed by electron paramagnetic resonance (EPR) spectroscopy with Fe-N, N-diethyldithiocarbamate (Fe-DETC) complex as a NO-trapping reagent in the rat liver during development. The NO production in the liver was increased at 3 weeks after birth and then declined. Administration of the NO synthase (NOS) inhibitor L-NAME suppressed the endogenous NO production and the hepatocyte proliferation in the rat liver at 3 weeks after birth. The phosphorylation level of NOS3 at Ser1177, the activating residue of the enzyme, was increased at 3 weeks after birth and then declined as well as the NO production pattern. These results suggest that NO is mainly synthesized by NOS3 up-regulated by phosphorylation at Ser1177 and enhances the hepatocyte proliferation in the rat liver at 3 weeks after birth. These findings provide a novel insight into the contribution of NO to hepatic growth and the liver maturation during development.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_24":{"attribute_name":"NII論文ID(NAID)","attribute_value_mlt":[{"subitem_description":"40016759596","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000244"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学大学院獣医学研究科"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Veterinary Medicine, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000244"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"滝沢, 達也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takizawa, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-04-17"}],"displaytype":"detail","filename":"bull_jau_vol17-18-231.pdf","filesize":[{"value":"170.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol17-18-231","url":"https://az.repo.nii.ac.jp/record/3927/files/bull_jau_vol17-18-231.pdf"},"version_id":"e8fb2c1d-e29f-4534-930a-f970b085f44b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肝臓におけるNO産生とその調節機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝臓におけるNO産生とその調節機構の解析"},{"subitem_title":"Developmental changes of NO production in neonata rat liver","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["339","468"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-02-21"},"publish_date":"2014-02-21","publish_status":"0","recid":"3927","relation_version_is_last":true,"title":["肝臓におけるNO産生とその調節機構の解析"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-12-19T05:58:07.884636+00:00"}