| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2020-03-31 |
| タイトル |
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タイトル |
Sulfoquinovosyl Acyl Panediol (SQAP) as a Radiation Sensitizer for Dogs with Tumors : A Pilot Study |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Dog |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Radiation sensitizer |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Radiotherapy |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sulfoquinovosyl monoacylglyceride |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Tumor |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| ページ属性 |
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内容記述タイプ |
Other |
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内容記述 |
P(論文) |
| 記事種別 |
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内容記述タイプ |
Other |
|
内容記述 |
症例報告 |
| 著者 |
Yoshioka, Chie
Maruo, Takuya
Nishiyama, Yuta
Hosaka, Soshi
Fukuyama, Yasuhiro
Sahara, Hiroki
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| Author ID |
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- |
| Author ID |
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000377 |
| Author ID |
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000619 |
| Author ID |
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- |
| Author ID |
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|
- |
| Author ID |
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- |
| Institution or Company |
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Veterinary Teaching Hospital, Azabu University |
| Institution or Company |
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Veterinary Teaching Hospital, Azabu University |
| Institution or Company |
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Veterinary Teaching Hospital, Azabu University |
| Institution or Company |
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Veterinary Teaching Hospital, Azabu University |
| Institution or Company |
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Veterinary Teaching Hospital, Azabu University |
| Institution or Company |
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Laboratory of Biology, School of Veterinary Medicine, Azabu University |
| Abstract |
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内容記述タイプ |
Other |
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内容記述 |
Sulfoquinovosylacylpanediol (SQAP) was discovered to be a radiation sensitizer in 1997. However, the safety of SQAP and radiotherapy to treat naturally occurring tumors in dogs remains unknown. The purpose of this study was to evaluate the safety of SQAP and hypofractionated radiotherapy in healthy beagle dogs, and dogs with tumors. Healthy beagle dogs were administered SQAP at doses of 0, 1, 2, 4, and 8 mg/kg for 5 consecutive days on the first week, while radiotherapy was performed once weekly for 4 weeks. Five dogs with soft tissue sarcoma, thyroid carcinoma, undifferentiated carcinoma, hemangiosarcoma, and liposarcoma were also enrolled in this prospective study. SQAP at 4 mg/kg was administered to the dogs with tumors. The adverse events of SQAP included angialgia in most cases. The adverse events of SQAP and radiotherapy were mild. The systemic administration of SQAP and concomitant radiotherapy appears to be safe for short-term use. |
| 書誌情報 |
麻布大学雑誌
en : Journal of Azabu University
巻 31,
p. 53-59,
発行日 2020-03-31
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| 出版者 |
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出版者 |
麻布大学 |
| Publisher |
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出版者 |
Azabu University |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-5880 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11561468 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| text version |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
bull_jau_vol31-053.pdf (343.7 kB)
