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ダイオキシン類の発がん性への影響
https://az.repo.nii.ac.jp/records/5171
https://az.repo.nii.ac.jp/records/5171ed650f06-2e75-4651-acdd-d968289332e0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bull_jau_vol13-14-313.pdf (273.0 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2006-01-01 | |||||||||||
| タイトル | ||||||||||||
| タイトル | ダイオキシン類の発がん性への影響 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Effect of Exposure to Dioxins, as Endocrine Disruptors, on Carcinogenesis | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| ページ属性 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | P(論文) | |||||||||||
| 記事種別 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 特集 | |||||||||||
| Type | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | FEATURE ARTICLES | |||||||||||
| 著者 |
和久井, 信
× 和久井, 信
× Wakui, Shin
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| 著者ID | ||||||||||||
| 000073 | ||||||||||||
| Author ID | ||||||||||||
| 000073 | ||||||||||||
| 所属機関 | ||||||||||||
| 麻布大学獣医学部 | ||||||||||||
| Institution or Company | ||||||||||||
| Graduate School of Veterinary Science, Azabu University | ||||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | PCB126胎生期曝露はN-methyl-N-nitorosourea誘発前立腺発癌を用量依存的に抑制することが明らかとなり,その原因の一つとして前立腺癌細胞におけるAndrogen Receptorの発現抑制が示唆された。PCB126胎生期曝露は雄ラットに対してAndrogen Receptorを介し抗アンドロゲン様に作用することが推定された。 | |||||||||||
| Abstract | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | Although polychlorinated biphenyls (PCBs) are fat-soluble environmental pollutants stored breast fatty tissue and secreted in milk, the precise evidence of carcinogenesis from exposure to PCBs remains unclear. The aim of this study was to investigate the dose-response relationship prenatal exposure of 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB126) for N-methl-N-nitrosourea (MNU) induced rat prostate carcinogenesis. Male Sprague-Dawley rats whose dams had been injected (i.g.) with 25pg, 2.5ng, 250ng, 7.5μg of PCB126/kg, or the vehicle, on days 13 to 19 post-conception. 12-weeks-old male offsprings were injected (i.v.) with 45 mg MNU/kg. The concentration of PCB126 in the liver of the 12-weeks-old was compared to the vehicle-group, found to be significantly higher in the 7.5μg-group, but other group was nearly to that of the vehicle group. The experiment was terminated when the pups were 75-weeks-old. The 7.5μg, 250ng and 2.5ng-group showed reduction of prostate carcinogenesis, but the 25pg revealed increases incidence of carcinoma that is a similar incidence of the vehicle-group. The present studies indicated that prenatal exposure of high to relatively low dose PCB126 acted as an inhibiting agent toward MNU-induced rat prostate carcinogenesis. This effect partly might be due to an inhibition of androgen receptor (AR) expression at prostate, as relatively low dose PCB126 injected group, such as the 2.5ng group, showed inhibition of AR expression at prostatic lesions. | |||||||||||
| 書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 13/14, p. 313-315, 発行日 2007-03-31 |
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| レポート・演題番号 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 麻布大学ハイテク・リサーチ・センター研究プロジェクト 研究サブ・グループ5 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 麻布大学 | |||||||||||
| Publisher | ||||||||||||
| 出版者 | Azabu University | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 1346-5880 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA11561468 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| text version | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| format | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
