{"_buckets": {"deposit": "b79f1451-8b2f-4c3f-9099-c10993d44e5d"}, "_deposit": {"created_by": 4, "id": "5158", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "5158"}, "status": "published"}, "_oai": {"id": "oai:az.repo.nii.ac.jp:00005158", "sets": ["217", "511"]}, "author_link": ["22420", "22419"], "item_12_biblio_info_16": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-03-31", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "263", "bibliographicPageStart": "261", "bibliographicVolumeNumber": "13/14", "bibliographic_titles": [{"bibliographic_title": "麻布大学雑誌"}, {"bibliographic_title": "Journal of Azabu University", "bibliographic_titleLang": "en"}]}]}, "item_12_description_13": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "今回我々は,テーラーメイド医療の一助として,肥満に関連する倹約遺伝子(β 3-ADRとPPARγ)および非定型抗精神病薬オランザピンの代謝に関与する薬物動態学関連遺伝子(オランザピン代謝酵素CYP1A2とCYP2D6)と,オランザピンの薬理効果や副作用の発症の脆弱性との相関について解析を行った。その結果,本研究の遺伝子多型および精神薬理学的解析から,CYP2D6欠損型遺伝子多型保持者はオランザピンの高血中濃度を示したが,それが必ずしも高血糖や体重増加にはつながらず,血糖値の上昇や体重の増加といったオランザピンの副作用と倹約遺伝子と薬物動態学関連遺伝子の多型においても相関はみられなかった。", "subitem_description_type": "Abstract"}]}, "item_12_description_14": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "We investigated the influence that the polymorphisms of Cytochrome P450 (CYP)gene, thrifty gene and pharmacodynamic related gene give to a side effect of Olanzapine to clarify the mechanism of the side effects of antipsychotic, Olanzapine. 16 schizophrenic patients (age-matched 5 with, and 10 patients without the side effects of hyperglysemia and more than 4kg body weight gain through the Olanzapine treatment). For the analysis of these gene polymorphisms, we amplified our objective region using the PCR (Polymerase Chain Reaction) method and then used the RFLP (Restriction Fragment Length Polymorphism) method for the actual evaluation and for the statistical analysis, we used Mann-Whitney\u0027s U Certification and X^2-test. However, there was no significant difference in the frequency of the mutant allele of Cytochrome P450 (CYP)gene, thrifty gene and pharmacodynamic related gene, between schizophrenia patients with and without the side effects of Olanzapine. These results suggested that drug-metabolism ability, thrifty-metabolism and pharmacodynamic neurotransmitter receptor/transporter investigated in this study may have no influence on the side effects of Olanzapine. Further studies with more subjects are needed to investigate other candidate genes for the side effects of antipsychotics.", "subitem_description_type": "Other"}]}, "item_12_description_2": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_12_description_3": {"attribute_name": "記事種別", "attribute_value_mlt": [{"subitem_description": "特集", "subitem_description_type": "Other"}]}, "item_12_description_34": {"attribute_name": "format", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_12_description_4": {"attribute_name": "Type", "attribute_value_mlt": [{"subitem_description": "FEATURE ARTICLES", "subitem_description_type": "Other"}]}, "item_12_publisher_19": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "麻布大学"}]}, "item_12_publisher_20": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Azabu University"}]}, "item_12_source_id_21": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1346-5880", "subitem_source_identifier_type": "ISSN"}]}, "item_12_source_id_23": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11561468", "subitem_source_identifier_type": "NCID"}]}, "item_12_text_10": {"attribute_name": "Author ID", "attribute_value_mlt": [{"subitem_text_value": "000278"}]}, "item_12_text_11": {"attribute_name": "所属機関", "attribute_value_mlt": [{"subitem_text_value": "麻布大学大学院環境保健学研究科"}]}, "item_12_text_12": {"attribute_name": "Institution or Company", "attribute_value_mlt": [{"subitem_text_value": "Laboratory of Neurophysiology the Graduate School of Environmental Health Sciences, Azabu Unuversity"}]}, "item_12_text_9": {"attribute_name": "著者ID", "attribute_value_mlt": [{"subitem_text_value": "000278"}]}, "item_12_version_type_29": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_12_version_type_30": {"attribute_name": "text version", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "岩橋, 和彦"}, {"creatorName": "イワハシ, カズヒコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "22419", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwahashi, Kazuhiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22420", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2006-01-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "bull_jau_vol13-14-261.pdf", "filesize": [{"value": "236.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 236400.0, "url": {"label": "bull_jau_vol13-14-261.pdf", "url": "https://az.repo.nii.ac.jp/record/5158/files/bull_jau_vol13-14-261.pdf"}, "version_id": "dba6dd47-0356-463f-aa67-71458715e012"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "非定型抗精神薬の効果と副作用に関する神経薬理学的研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "非定型抗精神薬の効果と副作用に関する神経薬理学的研究"}, {"subitem_title": "The influence that the polymorphisms of thrifty gene and pharmacodynamic related gene give to a side effect of antipsychotic, Olanzapine", "subitem_title_language": "en"}]}, "item_type_id": "12", "owner": "4", "path": ["217", "511"], "permalink_uri": "https://az.repo.nii.ac.jp/records/5158", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-01-01"}, "publish_date": "2006-01-01", "publish_status": "0", "recid": "5158", "relation": {}, "relation_version_is_last": true, "title": ["非定型抗精神薬の効果と副作用に関する神経薬理学的研究"], "weko_shared_id": 4}