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  1. 著者
  2. I
  3. 岩橋 和彦
  1. 紀要
  2. 麻布大学雑誌
  3. 麻布大学雑誌 Vol.13/14 (2006)

非定型抗精神薬の効果と副作用に関する神経薬理学的研究

https://az.repo.nii.ac.jp/records/5158
https://az.repo.nii.ac.jp/records/5158
c2bbab5a-a4c2-4203-b945-af6c5676f543
名前 / ファイル ライセンス アクション
bull_jau_vol13-14-261.pdf bull_jau_vol13-14-261.pdf (236.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-01
タイトル
タイトル 非定型抗精神薬の効果と副作用に関する神経薬理学的研究
タイトル
言語 en
タイトル The influence that the polymorphisms of thrifty gene and pharmacodynamic related gene give to a side effect of antipsychotic, Olanzapine
言語
言語 jpn
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
ページ属性
内容記述タイプ Other
内容記述 P(論文)
記事種別
内容記述タイプ Other
内容記述 特集
Type
内容記述タイプ Other
内容記述 FEATURE ARTICLES
著者 岩橋, 和彦

× 岩橋, 和彦

WEKO 22419

岩橋, 和彦

ja-Kana イワハシ, カズヒコ

Search repository
Iwahashi, Kazuhiko

× Iwahashi, Kazuhiko

WEKO 22420

en Iwahashi, Kazuhiko

Search repository
著者ID
000278
Author ID
000278
所属機関
麻布大学大学院環境保健学研究科
Institution or Company
Laboratory of Neurophysiology the Graduate School of Environmental Health Sciences, Azabu Unuversity
抄録
内容記述タイプ Abstract
内容記述 今回我々は,テーラーメイド医療の一助として,肥満に関連する倹約遺伝子(β 3-ADRとPPARγ)および非定型抗精神病薬オランザピンの代謝に関与する薬物動態学関連遺伝子(オランザピン代謝酵素CYP1A2とCYP2D6)と,オランザピンの薬理効果や副作用の発症の脆弱性との相関について解析を行った。その結果,本研究の遺伝子多型および精神薬理学的解析から,CYP2D6欠損型遺伝子多型保持者はオランザピンの高血中濃度を示したが,それが必ずしも高血糖や体重増加にはつながらず,血糖値の上昇や体重の増加といったオランザピンの副作用と倹約遺伝子と薬物動態学関連遺伝子の多型においても相関はみられなかった。
Abstract
内容記述タイプ Other
内容記述 We investigated the influence that the polymorphisms of Cytochrome P450 (CYP)gene, thrifty gene and pharmacodynamic related gene give to a side effect of Olanzapine to clarify the mechanism of the side effects of antipsychotic, Olanzapine. 16 schizophrenic patients (age-matched 5 with, and 10 patients without the side effects of hyperglysemia and more than 4kg body weight gain through the Olanzapine treatment). For the analysis of these gene polymorphisms, we amplified our objective region using the PCR (Polymerase Chain Reaction) method and then used the RFLP (Restriction Fragment Length Polymorphism) method for the actual evaluation and for the statistical analysis, we used Mann-Whitney's U Certification and X^2-test. However, there was no significant difference in the frequency of the mutant allele of Cytochrome P450 (CYP)gene, thrifty gene and pharmacodynamic related gene, between schizophrenia patients with and without the side effects of Olanzapine. These results suggested that drug-metabolism ability, thrifty-metabolism and pharmacodynamic neurotransmitter receptor/transporter investigated in this study may have no influence on the side effects of Olanzapine. Further studies with more subjects are needed to investigate other candidate genes for the side effects of antipsychotics.
書誌情報 麻布大学雑誌
en : Journal of Azabu University

巻 13/14, p. 261-263, 発行日 2007-03-31
出版者
出版者 麻布大学
Publisher
出版者 Azabu University
ISSN
収録物識別子タイプ ISSN
収録物識別子 1346-5880
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11561468
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
text version
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
format
内容記述タイプ Other
内容記述 application/pdf
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