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ラットにおけるα_1-酸性糖蛋白(α_1AG)の動態に関する研究
https://az.repo.nii.ac.jp/records/5150
https://az.repo.nii.ac.jp/records/5150a73566da-eae1-44ee-bbea-41b6ec1177eb
名前 / ファイル | ライセンス | アクション |
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bull_jau_vol13-14-222.pdf (292.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-01-01 | |||||
タイトル | ||||||
タイトル | ラットにおけるα_1-酸性糖蛋白(α_1AG)の動態に関する研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Variations of α_1-acid glycoprotein (α_1・AG) in healthy rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 特集 | |||||
Type | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEATURE ARTICLES | |||||
著者 |
栗林, 尚志
× 栗林, 尚志× 山本, 静雄× Kuribayashi, Takashi× Yamamoto, Shizuo |
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著者ID | ||||||
000345 | ||||||
著者ID | ||||||
000117 | ||||||
Author ID | ||||||
000345 | ||||||
Author ID | ||||||
000117 | ||||||
所属機関 | ||||||
麻布大学大学院環境保健学研究科 | ||||||
所属機関 | ||||||
麻布大学大学院環境保健学研究科 | ||||||
Institution or Company | ||||||
Azabu University, Graduate School of Environmental Health | ||||||
Institution or Company | ||||||
Azabu University, Graduate School of Environmental Health | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 異なる炎症刺激を与えて急性炎症を惹起させた9週齢のSprague-Dawley系雄性ラットにおいて,α_1-酸性糖蛋白(α_1・AG),インターロイキン(IL)1,6およびCytokine-induced neutrophil chemoattractant-1(CINC-1)の血清中濃度の推移を検討した。α_1・AGは,炎症刺激後48時間に最高値を示した。そのα_1・AG値は,テレピン油(0.4ml/head)投与例では投与前値の33.7倍で,インドメタシン(20mg/kg)投与例では投与前値の15.5倍であった。CINC-1は,テレピン油,インドメタシンおよび黄色ブドウ球菌投与後に増加し,投与12時間後に最高値を示した。しかし,IL-6は,テレピン油投与時のみに増加(最高値27.4倍)し,インドメタシンおよび黄色ブドウ球菌投与時には増加を示さなかった。テレピン油投与例でIL-1に変化は認められなかった。 | |||||
Abstract | ||||||
内容記述タイプ | Other | |||||
内容記述 | Serum levels of α_1・AG, IL-1, IL-6 and CINC-1 were estimated in twenty-five 9-week-old male SD rats following various types of acute inflammatory stimulation. Serum levels of α_1・AG and IL-6, CINC-1 were measured by SRID and ELISA, respectively, using commercial kits. α_1・AG increased after inflammatory stimulation and peak levels were observed after 48h. Serum levels of α_1・AG also increased after inoculation with S. aureus, but were scarcely increased after inoculation with P. aeruginosa. However, only CINC-1 increased after injection of indomethacin (20mg/kg); IL-6 levels did not change. This phenomenon was also observed in rats inoculated with S. aureus. IL-6 increased only after injection of turpentine oil and did not change after injection of indomethacin or inoculation with S. aureus. IL-1 did not change after injection of turpentine oil. α_1・AG is useful as an inflammatory marker in rats | |||||
書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 13/14, p. 222-225, 発行日 2007-03-31 |
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出版者 | ||||||
出版者 | 麻布大学 | |||||
Publisher | ||||||
出版者 | Azabu University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-5880 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11561468 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
text version | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
format | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |