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アイテム
ネコカリシウイルス(FCV)の分子多様性に関する研究
https://az.repo.nii.ac.jp/records/5135
https://az.repo.nii.ac.jp/records/51353ec4094b-25da-44ac-be1c-6dce0b67bd18
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bull_jau_vol13-14-151.pdf (304.8 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2006-01-01 | |||||||
| タイトル | ||||||||
| タイトル | ネコカリシウイルス(FCV)の分子多様性に関する研究 | |||||||
| タイトル | ||||||||
| タイトル | Study on the molecular variety of Feline calicivirus (FCV) | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| ページ属性 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | P(論文) | |||||||
| 記事種別 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 特集 | |||||||
| Type | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | FEATURE ARTICLES | |||||||
| 著者 |
原, 元宣
× 原, 元宣
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| 著者ID | ||||||||
| 000039 | ||||||||
| 所属機関 | ||||||||
| 麻布大学獣医学部獣医学科微生物学教室II | ||||||||
| Institution or Company | ||||||||
| Department of Microbiology II, School of Veterinary medicine, Azabu University | ||||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | 長期に渡る個体あるいは個体間のウイルス感染によりアミノ酸の変化の相違がクラスターに反映され排泄期間と関連するようである。持続感染と関連する置換部位として中和エピトープの存在する5'HVRの4箇所(434;D-H, 440: G-E, 450: A-K, 455: V-T)が関連している可能性が示唆された。また,突然死した猫から分離された株は以前報告された高病原性株と異なり,GA IIに属し上述の株とも異なっており,ワクチンブレイクとともにさら野外株の分子疫学的研究について検討する予定である。 | |||||||
| Abstract | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | It continues from the past, in an amino acid sequence of an Ao primer domain of all isolates, 2 genogroups were clustered with the bootstrap value that 98.3% were high, and 198-1 and 199-1 strains of 1st isolates were included in Genogroup I in the phylogenetic tree and were included in Genogroup II besides it. Genogroup II was divided into three Genogroups II b, II c with II a (212-1) and probability of 98.5% with probability of 96.1% more. Isolates from a kitten except 212-1 strain were included in Genogroup II b, and 3rd, 4th, 5th isolates was included in Genogroup II c for long period. Characteristic changes associated with inter individual transmission were found in 1 site in region C in which the neutralizing epitope resided (N at position 399 to D), and in 2 sites in the 5'HVR of region E (E at position 428 to K, and A at position 432 to T). Among the sites of substitutions specific to persistent infection, 4 sites in the 5'HVR of region E in which the neutralizing epitope resided (D to H at position 434, G to E at position 440, A to K at position 450, and V to T at position 455) may be related to escape mutation to escape from the antibody production. In addition, a strain isolated from the cat which died suddenly is different from high pathogenic strain reported previously, and it belongs to GA II, and it is different from field strains described above, and it is necessary to study further with a vaccine break more. | |||||||
| 書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 13/14, p. 151-154, 発行日 2007-03-31 |
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| 出版者 | ||||||||
| 出版者 | 麻布大学 | |||||||
| Publisher | ||||||||
| 出版者 | Azabu University | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1346-5880 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA11561468 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| text version | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| format | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
