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  1. 著者
  2. K
  3. 川上 泰
  1. 紀要
  2. 麻布大学雑誌
  3. 麻布大学雑誌Vol.15/16 (2007)

条虫類に存在する糖脂質の機能解析

https://az.repo.nii.ac.jp/records/5065
https://az.repo.nii.ac.jp/records/5065
cb3c219c-7d4e-4c60-9158-a3709ce6e6c1
名前 / ファイル ライセンス アクション
bull_jau_vol15-16-274.pdf bull_jau_vol15-16-274.pdf (266.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-01-01
タイトル
タイトル 条虫類に存在する糖脂質の機能解析
タイトル
言語 en
タイトル Role of glycosphingolipids isolated from tapeworms
言語
言語 jpn
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
ページ属性
内容記述タイプ Other
内容記述 P(論文)
記事種別
内容記述タイプ Other
内容記述 特集
Type
内容記述タイプ Other
内容記述 FEATURE ARTICLES
著者 川上, 泰

× 川上, 泰

WEKO 21988

川上, 泰

ja-Kana カワカミ, ヤスシ

Search repository
内田, 明彦

× 内田, 明彦

WEKO 21989

内田, 明彦

ja-Kana ウチダ, アキヒコ

Search repository
森田, 重光

× 森田, 重光

WEKO 21990

森田, 重光

ja-Kana モリタ, シゲミツ

Search repository
Kawakami, Yasushi

× Kawakami, Yasushi

WEKO 21991

en Kawakami, Yasushi

Search repository
Uchida, Akihiko

× Uchida, Akihiko

WEKO 21992

en Uchida, Akihiko

Search repository
Morita, Sigemitsu

× Morita, Sigemitsu

WEKO 21993

en Morita, Sigemitsu

Search repository
著者ID
000130
著者ID
-
著者ID
-
Author ID
000130
Author ID
-
Author ID
-
所属機関
麻布大学大学院環境保健学研究科環境保健科学専攻
所属機関
麻布大学大学院環境保健学研究科環境保健科学専攻
所属機関
麻布大学大学院環境保健学研究科環境保健科学専攻
Institution or Company
Course of Environmental Health Science, Azabu University
Institution or Company
Course of Environmental Health Science, Azabu University
Institution or Company
Course of Environmental Health Science, Azabu University
抄録
内容記述タイプ Abstract
内容記述 条虫から,生体膜上で集合してできると考えられている微小膜領域である膜ミクロドメインを調製し,糖脂質およびタンパク質糖鎖について実験を行った結果,低密度であるDIGs画分にAK97に反応する精脂質および精タンパクが局在していることがわかった。インフルエンザウイルスやヒト免疫不全ウイルス(HIV)の感染には精鎖が重要な役割を担うことが知られており,精鎖は条虫類の感染にも深く関与している可能性は極めて高く,固有宿主と非固有宿主を識別する因子として精脂質や精タンパク質のさらなる実験が必要であると考えられた。
Abstract
内容記述タイプ Other
内容記述 Detergent-insoluble glycolipid-enriched complexes (DIGs) formed as microdomains in the cell membranes have been shown to contain signalling molecules, cholesterol, glycosphingolipids and caveolae. DIGs can be expected to be involved in the mediation of host-parasite interactions. In this context, we have been studying DIGs of cestodes to elucidate underlying biochemical mechanisms of parasitism. We previously reported unique Glycosphingolipids, SEGLx and GalSEGLx, from the Pseudophyllidean tapeworms (Spirometra erinaceieuropaei). They were characterized by a carbohydrate structure Galβ1-4Glcβ-3Gal. We proposed a term "spirometosides" for glycolipids having this core (Kawakami et al. Eur. J. Biochem. 1996; 239; 905-11) and we also successively established a mouse monoclonal IgM antibody directed to SEGLx, and termed AK97 (Yanagisawa et al. Mol Biochem Parasitol. 1999; 102; 285-297). In this study, we analyzed worm proteins in DIG by western blotting using AK97. Fraction 6 and Fraction 7 were reacted with AK97. As anticipated, glycilipids were also present same fractions. Findings from this and our previous studies indicate that carbohydrate structures of "spirometosides" play significant roles in parasitic infection.
書誌情報 麻布大学雑誌
en : Journal of Azabu University

巻 15/16, p. 274-276, 発行日 2008-03-31
出版者
出版者 麻布大学
Publisher
出版者 Azabu University
ISSN
収録物識別子タイプ ISSN
収録物識別子 1346-5880
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11561553
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
text version
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
format
内容記述タイプ Other
内容記述 application/pdf
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