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精神活性物質依存関連の精神神経薬理的研究
https://az.repo.nii.ac.jp/records/4838
https://az.repo.nii.ac.jp/records/4838313842ad-051a-49d2-a0b0-ddd04b9b6db3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bull_jau_vol11-12-103.pdf (171.6 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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| 公開日 | 2005-01-01 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 精神活性物質依存関連の精神神経薬理的研究 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Neuropharmacological analysis of the neuro -activating substance | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| ページ属性 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | P(論文) | |||||||||||
| 記事種別 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 特集 | |||||||||||
| Type | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | FEATURE ARTICLES | |||||||||||
| 著者 |
岩橋, 和彦
× 岩橋, 和彦
× Iwahashi, Kazuhiko
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| 所属機関 | ||||||||||||
| 麻布大学環境保健学部 | ||||||||||||
| Institution or Company | ||||||||||||
| College of Environmental Health, Azabu University | ||||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | 精神活性物質のひとつでもある非定型抗精神病薬で,統合失調症治療の第一選択薬となりつつあるオランザピンの副作用である高血糖や体重増加の発症機序解明のためにその薬物代謝能と血中濃度や副作用の程度の相関を調べた。その結果,CYP2D6の低活性が血中オランザピンの高濃度を引き起こす可能性が示唆された。副作用の高血糖に関しては,オランザピンの高血中濃度が必ずしもその原因となるとはいえず,倹約遺伝子との相関も調べたが,いまのところ明らかな相関は見られなかった。 | |||||||||||
| Abstract | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | We examined the drug metabolism ability and blood concentration and correlation of degree of a side effect for onset mechanism elucidation of psycho-activating substances. We examined the metabolism ability and blood concentration and correlation of degree of the hyperglycosemia that was a side effect of olanzapine becoming a first-line drug of schizophrenia treatment, one of the psycho-activating substances. After informed concent was obtained, PCR was permormed with genomic DNA from 16 schizophrenic patients who were treated with olanzapine. We used PCR method and, about active individual difference of representative drug metabolizing enzyme such as CYP2D6 and CYP1A2, analyzed it. The Trp64Arg variant of the beta3-adrenergic receptor (beta3-AR) gene is relatively common in Japanese people. We hypothesized that this variant may be associated with obesity and insulin resistance when combined with olanzapine.But there is no association between the Trp64Arg variant of the beta3-AR gene and hyperglysemia, the side effects of olanzapine in Japanese schizophrenic patients. As a result, the possibility that low activity of CYP2D6 caused high level of blood olanzapine was suggested. It cannot be always said that high blood concentration of olanzapine caused hyperglycosemia of this side effect. To elucidate the mechanism of effects and side effect of psychotrophic drug such as antipsychotics, it may be important to examine the relationship between personal drug metabolism ability and characteristics of neurotransmitter-receptors such as 5HTR2A, and irritability for side effects. | |||||||||||
| 書誌情報 |
麻布大学雑誌 en : Journal of Azabu University 巻 11/12, p. 103-105, 発行日 2006-03-31 |
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| 出版者 | ||||||||||||
| 出版者 | 麻布大学 | |||||||||||
| Publisher | ||||||||||||
| 出版者 | Azabu University | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 1346-5880 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA11561468 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| text version | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| format | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
