| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2004-01-01 |
| タイトル |
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タイトル |
精神作用物質の依存および副作用に関連する遺伝子解析 : OlanzapineのCYP1A2およびCYP2D6による代謝 |
| タイトル |
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タイトル |
Analysis of Neurotropic dugs in dependence and side effects : Olanzapine metabolism by CYP1A2/CYP2D6 and fatality from hyperglycemia |
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言語 |
en |
| 言語 |
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言語 |
jpn |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| ページ属性 |
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内容記述タイプ |
Other |
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内容記述 |
P(論文) |
| 記事種別 |
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内容記述タイプ |
Other |
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内容記述 |
特集 |
| Type |
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内容記述タイプ |
Other |
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内容記述 |
FEATURE ARTICLES |
| 著者 |
岩橋, 和彦
吉原, 英児
高田, 直子
Iwahashi, Kazuhiko
Yoshihara, Eiji
Takada, Naoko
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| 著者ID |
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000278 |
| 著者ID |
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000126 |
| 著者ID |
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500498 |
| Author ID |
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000278 |
| Author ID |
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000126 |
| Author ID |
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500498 |
| 所属機関 |
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麻布大学大学院環境保健学研究科 神経生理学 |
| 所属機関 |
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麻布大学大学院環境保健学研究科 神経生理学 |
| 所属機関 |
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麻布大学大学院環境保健学研究科 生活環境学 |
| Institution or Company |
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Laboratory of Neurophysiology, Graduate School of Environmental Health Sciences, Azabu University |
| Institution or Company |
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Laboratory of Neurophysiology, Graduate School of Environmental Health Sciences, Azabu University |
| Institution or Company |
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Laboratory of Enviro, emtal Hygiene, Graduate School of Environmental Health Sciences, Azabu University |
| Abstract |
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内容記述タイプ |
Other |
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内容記述 |
Neuroleptics Olanzapine is conjugated and oxidized mainly by CYP1A2/CYP2D6. Human CYP1A2 in the 5'-flanking region and intron nucleotide sequence alalysis revealed the existence of a point mutation (-3858) from guanine (wild type; wt) to adenine (mutated type; 1C) caused a significant decrease of enzyme activity, from cytosine (-164) to adenine (mutated; 1F) caused higher inducibility of CYP1A2. Human CYP2D6 (wild type; 1) were also identified; As for the poor metabolizer, nucleotide sequence alalysis reveale the gene deletion (mutated type; 5) caused a deletion of enzyme activity, from cytosine (100) to thymine (mutated; 10) caused a enzyme activity decrease of CYP2D6. A potential side-effects during the treatment with olanzapine is hyperglycemia and newonset diabetes mellitus. There are possible mechanisms by which olanzapine could interfere with glucose metabolism. In this study, we investigate the relationship between olanzapine metabolism by CYP1A2/CYP2D6 and the side effect (fatality from hyperglysemia) to serve as an aid to solve the mechanisms of olanzapine induced abnormal glucose metabolism into diabetes mellitus among 12 Japanese schizophrenic patients. There were 3 patients whose CYP genotypes showed CYP1A2 1C/wt or CYP2D6 10/10, and whose blood olanzapine concentration was higher (about 40.0ng/mL) inspite of within 10mg daily dose. All these 3 patients did not show hyperglysemia, but other 3 patients whose CYP genotypes were normal, showed hyperglycemia. These results suggested that the higher blood olanzapine concentration may be effected by the abnormal metabolism by CYP1A2 and/or CYP2D6, but not always caused hyper glycemia. |
| 書誌情報 |
麻布大学雑誌
en : Journal of Azabu University
巻 9/10,
p. 123-126,
発行日 2005-03-31
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| 出版者 |
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出版者 |
麻布大学 |
| Publisher |
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出版者 |
Azabu University |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-5880 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11561468 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| text version |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
bull_jau_vol9-10-123.pdf (341.8 kB)
