| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2014-02-21 |
| タイトル |
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タイトル |
胎生期PCB曝露ラットの精子形成障害 |
| タイトル |
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タイトル |
Testicular toxicology of rats prenatally exposure to 3,3',4,4',5-pentachlorobiphenyl |
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言語 |
en |
| 言語 |
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言語 |
jpn |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| ページ属性 |
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内容記述タイプ |
Other |
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内容記述 |
P(論文) |
| 記事種別 |
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内容記述タイプ |
Other |
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内容記述 |
特集 |
| Type |
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内容記述タイプ |
Other |
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内容記述 |
FEATURE ARTICLES |
| 著者 |
和久井, 信
髙木, 敬彦
Wakui, Shin
Takagi, Yukihiko
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| 著者ID |
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000073 |
| 著者ID |
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000068 |
| Author ID |
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000073 |
| Author ID |
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000068 |
| 所属機関 |
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麻布大学大学院獣医学研究科 |
| 所属機関 |
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麻布大学大学院獣医学研究科 |
| Institution or Company |
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Graduate School of Veterinary Science, Azabu University |
| Institution or Company |
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Graduate School of Veterinary Science, Azabu University |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
内分泌かく乱化学物質である3,3',4,4',5-pentachlorobipheny胎生期曝露後のラット精巣の変化に関して生後7週齢・17週齢に形態学的に検討した。高用量曝露群では思春期から成獣期においてspermatogonia, spermatidsに障害が認められた。また, 低用量群では思春期ではspermatidsに障害が認められたが, 成獣期では回復する可逆的障害であることが示唆された。 |
| Abstract |
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内容記述タイプ |
Other |
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内容記述 |
The present study investigated the dose-response relationship in testicular toxicology of 7 (pubescent)- and 17 (adult)-week-old Sprague-Dawley rats whose dams had been injected (i.g.) with 25 pg, 2.5 ng, 250 ng, or 7.5 μg of 3,3',4,4',5-pentachlorobiphenyl (PCB 126)/kg or the vehicle on days 13 to 19 post-conception. At 7 and 17 weeks old of the 7.5 μg group and at 7 weeks old of the 250 ng group showed an increase in the percentage of seminiferous tubules at Stages VII-VIII. At 7 and 17 weeks old, the 7.5 μg group showed a decrease in preleptotene spermatocytes with spermatids at all Stages; while the 250 ng group also showed a decrease in preleptotene spermatocytes, but round spermatids increased at Stages VI-VII and elongated spermatids decreased at Stage VIII. At 7 weeks old, the 2.5 ng group showed an increase in round spermatids at Stages VI-VII. The formation of spermatogenic cells in the 25 pg group was similar to that of the vehicle group. The number of Sertoli cells and cauda epididymal sperms in the PCB 126 groups were similar to those of the vehicle group. Prenatal PCB126 exposure induced dose-related defective spermatogenesis. A high dose PCB126 group affected the development of spermatogonia and spermatids in puberty and adulthood, while a low dose group affected the conversion of spermatids at puberty, although this was recovered in adulthood. Because the serum testosterone levels were similar in the PCB126 and vehicle groups in puberty and adulthood, a direct endocrine cause for the observed effects was unlikely. |
| 書誌情報 |
麻布大学雑誌
en : Journal of Azabu University
巻 17/18,
p. 108-111,
発行日 2009-03-31
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| 出版者 |
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出版者 |
麻布大学 |
| Publisher |
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出版者 |
Azabu University |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-5880 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11561468 |
| NII論文ID(NAID) |
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内容記述タイプ |
Other |
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内容記述 |
40016759571 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| text version |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| format |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
bull_jau_vol17-18-108 (249.8 kB)
