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Evaluation of dose-dependent effects of dapagliflozin on urinary glucose and plasma ketone bodies in healthy dogs
https://az.repo.nii.ac.jp/records/2000584
https://az.repo.nii.ac.jp/records/200058409a3016f-68c9-430d-919b-3b143806c5a3
| 名前 / ファイル | ライセンス | アクション |
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Evaluation of dose-dependent effects of dapagliflozin on urinary glucose and plasma ketone bodies in healthy dogs.pdf (1004 KB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2026-05-20 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Evaluation of dose-dependent effects of dapagliflozin on urinary glucose and plasma ketone bodies in healthy dogs | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Umezawa, Mutsuki
× Umezawa, Mutsuki
× Orito, Kensuke
× Yoshimoto, Ryo
× Fujii, Yoko
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| Abstract | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Objective To evaluate the dose-dependent effects of single dosing of dapagliflozin on pharmacodynamics, diuresis, and ketogenesis in dogs. Methods This study included 5 healthy Beagles. A single dose of dapagliflozin (0.1, 0.3, or 1.0 mg/kg) or placebo was orally administered (randomized 14-day intervals) to each dog. Blood and urine samples were collected prior to administration and at 1, 2, 3, 4, 5, 6, 9, 12, and 24 hours after administration. A urinary catheter was placed from 0 to 6 hours after administration to monitor urine volume and collect samples; thereafter, urine was collected using a metabolic cage. Plasma ketone bodies, sodium, potassium, chloride, and glucose concentrations were measured. Urinary sodium, potassium, chloride, glucose, and urine volume were measured and compared among the treatment groups. Results 24-hour urinary glucose excretion was significantly increased in the 0.3-mg/kg group compared with the 0.1-mg/ kg group. However, no significant difference in 24-hour urinary glucose excretion was observed between the 0.3-and 1.0-mg/kg groups. Plasma ketone body concentration was significantly higher in the 1.0-mg/kg group compared with the placebo group at 4, 5, 6, 12, and 24 hours after administration. The 6-hour urine volume (mL/kg) was significantly higher in the 1.0-mg/kg group compared with the placebo group. Conclusions In healthy dogs, a single oral administration of dapagliflozin at 1.0 mg/kg induced both ketogenic and diuretic effects. Clinical Relevance This study provides preliminary insight into dapagliflozin’s effects in healthy dogs; further studies are needed to assess relevance in dogs with heart failure. | |||||||||||||
| 言語 | en | |||||||||||||
| 書誌情報 |
en : American journal of veterinary research 巻 87, 号 5, p. 1-7, ページ数 7, 発行日 2026-01-27 |
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| 出版者 | ||||||||||||||
| 出版者 | American Veterinary Medical Association | |||||||||||||
| 言語 | en | |||||||||||||
| DOI | ||||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.2460/ajvr.25.11.0390 | |||||||||||||
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| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 査読の有無 | Peer reviewed | |||||||||||||
