| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-10 |
| タイトル |
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タイトル |
SQAP, an acyl sulfoquinovosyl derivative, suppresses expression of histone deacetylase and induces cell death of cancer cells under hypoxic conditions |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kawakubo, Hirofumi
Kamisuki, Shinji
Suzuki, Kei
Izaguirre-Carbonell, Jesus
Saito, Shiki
Murata, Hiroshi
Tanabe, Atsushi
Hongo, Ayumi
Murakami, Hironobu
Matsunaga, Sachihiro
Sakaguchi, Kengo
Sahara, Hiroeki
Sugawara, Fumio
Kuramochi, Kouji
|
| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
Sulfoglycolipid, SQAP, is a radiosensitizing agent that makes tumor cells more sensitive to radiation therapy. A previous study revealed that SQAP induced the degradation of hypoxia-inducible factor-1α (HIF-1α) and inhibited angiogenesis in a hepatoma model mouse. Herein, we examined the biological activities of SQAP against hepatocarcinoma cells under low oxygen conditions. Cell growth inhibition of SQAP under hypoxic conditions was significantly higher than that under normoxic conditions. In addition, SQAP was found to impair the expression of histone deacetylase (HDAC) under low oxygen conditions. Our present data suggested that SQAP induced the degradation of HIF-1α and then decreased the expression of HDAC1. Unlike known HDAC inhibitors, SQAP increased the acetylation level of histone in cells without inhibition of enzymatic activity of HDACs. Our data demonstrated hypoxia-specific unique properties of SQAP. |
|
言語 |
en |
| 書誌情報 |
Bioscience, Biotechnology, and Biochemistry
巻 85,
号 1,
p. 85-91,
発行日 2021-01-07
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| 出版者 |
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出版者 |
Oxford University Press (OUP) |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1093/bbb/zbaa015 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 査読 |
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|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
Kawakubo BBB.pdf (529 KB)
