| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-10 |
| タイトル |
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|
タイトル |
Identification of methylsulochrin as a partial agonist for aryl hydrocarbon receptors and its antiviral and anti-inflammatory activities |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Nakamura, Kou
Yamasaki, Masako
Ohashi, Hirofumi
Saito, Shiki
Ashikawa, Koudai
Sato, Kanna
Nishioka, Kazane
Suzuki, Yuka
Tsurukawa, Yukine
Kanno, Kazuki
Mosu, Nozomi
Murakami, Hironobu
Nagane, Masaki
Okada, Maiko
Watashi, Koichi
Kamisuki, Shinji
|
| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
Although aryl hydrocarbon receptors (AhRs) are related to the metabolic pathway of xenobiotics, recent studies have revealed that this receptor is also associated with the life cycle of viruses and inflammatory reactions. For example, flutamide, used to treat prostate cancer, inhibits hepatitis C virus proliferation by acting as an AhR antagonist, and methylated-pelargonidin, an AhR agonist, suppresses pro-inflammatory cytokine production. To discover a novel class of AhR ligands, we screened 1000 compounds derived from fungal metabolites using a reporter assay and identified methylsulochrin as a partial agonist of the aryl hydrocarbon receptor. Methylsulochrin was found to inhibit the production of hepatitis C virus (HCV) in Huh-7.5.1 cells. Methylsulochrin also suppressed the production of interleukin-6 in RAW264.7 cells. Furthermore, a preliminary structure-activity relationship study using sulochrin derivatives was performed. Our findings suggest the use of methylsulochrin derivatives as anti-HCV compounds with anti-inflammatory activity. |
|
言語 |
en |
| 書誌情報 |
Chemical and Pharmaceutical Bulletin
巻 71,
号 8,
p. 650-654,
発行日 2023-08-01
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| 出版者 |
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|
出版者 |
The Pharmaceutical Society of Japan |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1248/cpb.c23-00243 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 査読 |
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|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
nakamura_CPB.pdf (423 KB)
