| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-10 |
| タイトル |
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|
タイトル |
Acute type adult T-cell leukemia cells proliferate in the lymph nodes rather than in peripheral blood |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Mizuguchi, Mariko
Takatori, Mitsuyoshi
Sakihama, Shugo
Yoshita-Takahashi, Manami
Imaizumi, Naoki
Takahashi, Yoshiaki
Hasegawa, Hiroo
Karube, Kennosuke
Fukushima, Takuya
Nakamura, Masataka
Tanaka, Yuetsu
|
| Abstract |
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内容記述タイプ |
Abstract |
|
内容記述 |
A massive increase in the number of mature CD4+ T-cells in peripheral blood (PB) is a defining characteristic of acute type of adult T-cell leukemia (ATL). To date, the site of proliferation of ATL cells in the body has been unclear. In an attempt to address this question, we examined the expression of the proliferation marker, Ki-67, in freshly isolated ATL cells from PB and lymph nodes (LNs) of patients with various types of ATL. Our findings reveal that LN-ATL cells display higher expression of the Ki-67 antigen than PB-ATL cells in acute type patients. The gene expression of T-cell quiescence regulators such as Krüppel-like factor 2/6 and forkhead box protein 1 was substantially high in acute type PB-ATL cells. The expression of human telomerase reverse transcriptase, which is involved in T-cell expansion, was significantly low in PB-ATL cells from acute type patients, similar to that in normal resting T-cells. These findings suggest that ATL cells proliferate in the LNs rather than in PB. |
|
言語 |
en |
| 書誌情報 |
Cancer Gene Therapy
巻 29,
号 11,
p. 1570-1577,
発行日 2022-04-22
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| 出版者 |
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|
出版者 |
Springer Science and Business Media LLC |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0929-1903 |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41417-022-00475-0 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
2022_CGT_mizuguchi.pdf (6 MB)
