| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-13 |
| タイトル |
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|
タイトル |
Specific antiviral effect of violaceoid E on bovine leukemia virus |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Murakami, Hironobu
Murakami-Kawai, Makoto
Kamisuki, Shinji
Shibasaki, Hisanobu
Tsurukawa, Yukine
Uchiyama, Jumpei
Sakaguchi, Masahiro
Tsukamoto, Kenji
|
| Abstract |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Bovine leukemia virus (BLV) infection has spread worldwide causing significant economic losses in the livestock industry. In countries with a high prevalence of BLV, minimizing economic losses is challenging; thus, research into various countermeasures is important for improving BLV control. Because anti-BLV drugs have not been developed, the present study explored a promising chemical compound with anti-BLV activity. Initially, screening of a chemical compound library revealed that violaceoid E (vioE), which is isolated from fungus, showed antiviral activity. Further analysis demonstrated that the antiviral effect of vioE inhibited transcriptional activation of BLV. Cellular thermal shift assay and pulldown assays provided evidence for a direct interaction between vioE and the viral transactivator protein, Tax. These data indicate that interference with Tax-dependent transcription could be a novel target for development of anti-BLV drugs. Therefore, it is suggested that vioE is a novel antiviral compound against BLV. |
|
言語 |
en |
| 書誌情報 |
Virology
巻 562,
p. 1-8,
発行日 2021-10
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| 出版者 |
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|
出版者 |
Elsevier BV |
| DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.virol.2021.06.010 |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
