| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-13 |
| タイトル |
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|
タイトル |
Endothelial ganglioside GM3 regulates angiogenesis in solid tumors |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Suzuki, Mira
Nagane, Masaki
Kato, Kazuhiro
Yamauchi, Akinori
Shimizu, Takuto
Yamashita, Hiroko
Aihara, Naoyuki
Kamiie, Junichi
Kawashima, Nagako
Naito, Shokichi
Yamashita, Tadashi
|
| Abstract |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Cancer cells require oxygen and nutrients for growth, making angiogenesis one of the essential components of tumor growth. Gangliosides, constituting membrane lipid rafts, regulate intracellular signal transduction and are involved in the malignancy of cancer cells. While endothelial cells, as well as cancer cells, express vast amounts of gangliosides, the precise function of endothelial gangliosides in angiogenesis remains unclear. In this study, we focused on gangliosides of vascular endothelial cells and analyzed their functions on tumor angiogenesis. In human breast cancer, GM3 synthase was highly expressed in vascular endothelial cells as well as immune cells. Angiogenesis increased in GM3S-KO mice. In BAEC, RNA interference of GM3S showed increased cellular invasion and oxidative stress tolerance through activation of ERK. In the breast cancer model, GM3-KO mice showed an increase in tumor growth and angiogenesis. These results suggest that the endothelial ganglioside GM3 regulates tumor angiogenesis by suppressing cellular invasion and oxidative stress tolerance in endothelial cells. |
|
言語 |
en |
| 書誌情報 |
Biochemical and biophysical research communications
巻 569,
p. 10-16,
発行日 2021-09-10
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| 出版者 |
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|
出版者 |
Elsevier BV |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.bbrc.2021.06.063 |
| 査読 |
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内容記述タイプ |
Other |
|
内容記述 |
査読あり |
