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DNA Damage Response Regulation by Histone Ubiquitination
https://az.repo.nii.ac.jp/records/2000308
https://az.repo.nii.ac.jp/records/2000308606d617c-19e1-4e80-9a80-1eb0e6d5a786
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ijms-23-08187-v2.pdf (824 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2025-02-14 | |||||||||
| タイトル | ||||||||||
| タイトル | DNA Damage Response Regulation by Histone Ubiquitination | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Sekiguchi, Miyu
× Sekiguchi, Miyu
× Matsushita, Nobuko
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| Abstract | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Cells are constantly exposed to numerous genotoxic stresses that induce DNA damage. DNA double-strand breaks (DSBs) are among the most serious damages and should be systematically repaired to preserve genomic integrity. The efficiency of repair is closely associated with chromatin structure, which is regulated by posttranslational modifications of histones, including ubiquitination. Recent evidence shows crosstalk between histone ubiquitination and DNA damage responses, suggesting an integrated model for the systematic regulation of DNA repair. There are two major pathways for DSB repair, viz., nonhomologous end joining and homologous recombination, and the choice of the pathway is partially controlled by posttranslational modifications of histones, including ubiquitination. Histone ubiquitination changes chromatin structure in the vicinity of DSBs and serves as a platform to select and recruit repair proteins; the removal of these modifications by deubiquitinating enzymes suppresses the recruitment of repair proteins and promotes the convergence of repair reactions. This article provides a comprehensive overview of the DNA damage response regulated by histone ubiquitination in response to DSBs. | |||||||||
| 言語 | en | |||||||||
| 書誌情報 |
International Journal of Molecular Sciences 巻 23, 号 15, p. 8187-8187, 発行日 2022-07-25 |
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| 出版者 | ||||||||||
| 出版者 | MDPI AG | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.3390/ijms23158187 | |||||||||
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| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 査読 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 査読あり | |||||||||
