| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-03 |
| タイトル |
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タイトル |
Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Namiki, Takafumi
Terakawa, Jumpei
Karakama, Harumi
Noguchi, Michiko
Murakami, Hironobu
Hasegawa, Yoshinori
Ohara, Osamu
Daikoku, Takiko
Ito, Junya
Kashiwazaki, Naomi
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| Abstract |
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内容記述タイプ |
Abstract |
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内容記述 |
Leukemia inhibitory factor (LIF) receptor, an interleukin 6 cytokine family signal transducer (Il6st, also known as Gp130) that is expressed in the uterine epithelium and stroma, has been recognized to play an essential role in embryo implantation. However, the molecular mechanism underlying Gp130-mediated LIF signaling in the uterine epithelium during embryo implantation has not been elucidated. In this study, we generated mice with uterine epithelium specific deletion of Gp130 (Gp130 ecKO). Gp130 ecKO females were infertile due to the failure of embryo attachment and decidualization. Histomorphological observation revealed that the endometrial shape and embryo position from Gp130 ecKO were comparable to those of the control, and uterine epithelial cell proliferation, whose attenuation is essential for embryo implantation, was controlled in Gp130 ecKO. Comprehensive gene expression analysis using RNA-seq indicates that epithelial Gp130 regulates the expression of estrogen- and progesterone-responsive genes in conjunction with immune response during embryo implantation. We also found that an epithelial remodeling factor, snail family transcriptional repressor 1 (Snai1), was markedly reduced in the pre-implantation uterus from Gp130 ecKO. These results suggest that not only the suppression of uterine epithelial cell proliferation, but also Gp130-mediated epithelial remodeling is required for successful implantation in mice. |
|
言語 |
en |
| 書誌情報 |
Scientific reports
巻 13,
号 1,
p. 854-854,
発行日 2023-01-16
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| 出版者 |
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出版者 |
Springer Nature |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-023-27859-y |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
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|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
s41598-023-27859-y.pdf (2.7 MB)
