| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-12-13 |
| タイトル |
|
|
タイトル |
Zinc transporter ZnT3/Slc30a3 has a potential role in zinc ion influx in mouse oocytes |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kageyama, Atsuko
Terakawa, Jumpei
Takarabe, Shunsuke
Sugita, Hibiki
Kawata, Yui
Ito, Junya
Kashiwazaki, Naomi
|
| Abstract |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Zinc is an essential trace element for various physiological functions, including reproduction. The influx/efflux of zinc ions is regulated by zinc transporters (Zip1-14 and ZnT1-8, 10). However, the precise roles of zinc transporters and zinc dynamics in reproductive functions are unknown. In this study, ZnT3/Slc30a3 gene knockout (KO) mice were used to analyze the role of ZnT3. In ZnT3 KO mice, intracellular zinc ions in oocytes/zygotes were significantly reduced compared to those in controls, and free zinc ions did not accumulate in the oocyte cytoplasm. However, fertilization of these oocytes and the average litter size were comparable to those of control mice. Our results suggest that ZnT3 plays an important role in the accumulation of zinc ions in oocytes but not in the developmental ability of mice. ZnT3 KO mice will be useful for examining zinc dynamics in oocytes and other tissues. |
|
言語 |
en |
| 書誌情報 |
Journal of Reproduction and Development
巻 70,
号 5,
p. 338-342,
発行日 2024-07
|
| 出版者 |
|
|
出版者 |
Japanese Society of Animal Reproduction |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0916-8818 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1262/jrd.2024-044 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 査読 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
査読あり |
70_2024-044.pdf (3.6 MB)
