{"created":"2023-06-19T07:19:13.870181+00:00","id":5170,"links":{},"metadata":{"_buckets":{"deposit":"9093176c-1a49-4b49-b568-7a8bd708f471"},"_deposit":{"created_by":4,"id":"5170","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"5170"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00005170","sets":["17:37:227","17:40:280","31:181:511"]},"author_link":["22498","22497","22500","22499","22501","22502"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"312","bibliographicPageStart":"309","bibliographicVolumeNumber":"13/14","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マスト細胞は,自然免疫および適応免疫において様々なメディーターを放出することにより細菌感染免疫応答関与している。PCB126のマスト細胞免疫応答に対する影響を調べるため,PCB126前処理マスト細胞におけるLPS刺激によるサイトカイン誘導能とその関連分子について検討した。LPS刺激によりマスト細胞は前炎症性サイトカイン,ケモカインの遺伝子および蛋白発現が上昇するが,PCB126で前処理されたマスト細胞ではその発現が阻害された。Cq1はPCB126特異的にマスト細胞内で強く誘導された。Cq1蛋白の作用機序がNFκBを利用することから,PCB126によるLPS刺激後のマスト細胞サイトカイン産生抑制はNFκBにおける競合による可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Mast cells are involved in innate and Adaptec immune responses of bacterial infection by releasing various mediators. To investigate the influence of coplanar PCB126 in mast cell, gene expression of mediators and Cq1 which has an important role in immune-responses was assessed. Gene expression of mediator increased in mast cell stimulated with LPS, but rather inhibited them in PCB126 pretreatment mast cell with LPS. Gene expression of Cq1 which use the activation of transcription factor of the NFkB family was strongly and contentiously detected in PCB126 treat mast cell. Our results suggest the possibility that PCB126 may inhibit gene expression of mediators in mast cell by competing with NFkB molecules.","subitem_description_type":"Other"}]},"item_12_description_18":{"attribute_name":"レポート・演題番号","attribute_value_mlt":[{"subitem_description":"麻布大学ハイテク・リサーチ・センター研究プロジェクト 研究サブ・グループ4","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000065"},{"subitem_text_value":"-"},{"subitem_text_value":"000259"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"School of Veterinary Medicine, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000065"},{"subitem_text_value":"-"},{"subitem_text_value":"000259"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 輝雄"},{"creatorName":"イケダ, テルオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"舟場, 正幸"},{"creatorName":"フナバ, マサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村上, 賢"},{"creatorName":"ムラカミ, マサル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Teruo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Funaba, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2006-01-01"}],"displaytype":"detail","filename":"bull_jau_vol13-14-309.pdf","filesize":[{"value":"388.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol13-14-309.pdf","url":"https://az.repo.nii.ac.jp/record/5170/files/bull_jau_vol13-14-309.pdf"},"version_id":"43d30e03-78c1-47ac-bccb-6e4e021faa41"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響"},{"subitem_title":"The effects of Co-PCB in allergic disorder : Analyses of mast cell functions in response to Co-PCB.","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["227","280","511"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-01-01"},"publish_date":"2006-01-01","publish_status":"0","recid":"5170","relation_version_is_last":true,"title":["マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:50:08.734113+00:00"}