{"created":"2023-06-19T07:19:11.939106+00:00","id":5125,"links":{},"metadata":{"_buckets":{"deposit":"bbd38515-176b-4f9a-8338-aa7ae40b1660"},"_deposit":{"created_by":4,"id":"5125","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"5125"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00005125","sets":["17:37:227","17:40:280","31:181:511"]},"author_link":["22223","22226","22225","22224","22228","22227"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"119","bibliographicPageStart":"117","bibliographicVolumeNumber":"13/14","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マスト細胞がアレルギーや感染局所などの免疫応答部位で増殖していることはよく知られているが,その増殖機構については現在までよく知られていない。そこでLPS刺激に対して変動する遺伝子群の中から増殖に関連する遺伝子について検討した。すでに我々が報告したIL-3以外に増殖に関連する遺伝子としてIL-9が見られ,その発現は免疫応答の経過およびLPS濃度依存的に増加し,MTTアッセイの結果から,増殖に関係するものであった。これらの結果から,グラム陰性桿菌感染におけるマスト細胞免疫応答における局所でのマスト細胞の増殖には,自然免疫初期ではIL-3が,自然免疫および獲得免疫でIL-9が関与することが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"It is well known that mast cell proliferation is shown in the infectious site of bacteria. However the mechanism of mast cell proliferation in infectious site is unclear at present. The up-regulated genes in mast cell induced with LPS were proimflamatory and Th2 cytokaines. Among these genes, expression of IL-9, is known as inducible cytokine to proliferate mast cell, was up-regulated dependent on time and LPS concentration. It is shown that mast cell proliferation following LPS stimulation is due to the mast cell growth-promoting cytokine IL-9 from MTT assay with anti-IL-9. Our results suggest that mast cell proliferation in infectious site is regulated with both IL-3 and IL-9 alone or in combination.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000065"},{"subitem_text_value":"-"},{"subitem_text_value":"000259"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部病態生化学・免疫学研究室"},{"subitem_text_value":"麻布大学栄養学研究室"},{"subitem_text_value":"麻布大学分子生物学研究室"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Laboratoty of Pathobiochemistry and Immunology"},{"subitem_text_value":"Nutrition"},{"subitem_text_value":"Molecular Biology, School of Medicine, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000065"},{"subitem_text_value":"-"},{"subitem_text_value":"000259"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 輝雄"},{"creatorName":"イケダ, テルオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"舟場, 正幸"},{"creatorName":"フナバ, マサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村上, 賢"},{"creatorName":"ムラカミ, マサル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Teruo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Funaba, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2006-01-01"}],"displaytype":"detail","filename":"bull_jau_vol13-14-117.pdf","filesize":[{"value":"261.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol13-14-117.pdf","url":"https://az.repo.nii.ac.jp/record/5125/files/bull_jau_vol13-14-117.pdf"},"version_id":"22b2170a-f0fc-4f17-a5eb-924acac222d4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"免疫応答におけるマスト細胞活性化機構に関する研究 : Toll-like receptorによるマスト細胞の活性化について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫応答におけるマスト細胞活性化機構に関する研究 : Toll-like receptorによるマスト細胞の活性化について"},{"subitem_title":"Activating mechamism of mast cell in immuno-responses : mast cell activation the to Toll-like receptor","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["227","280","511"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-01-01"},"publish_date":"2006-01-01","publish_status":"0","recid":"5125","relation_version_is_last":true,"title":["免疫応答におけるマスト細胞活性化機構に関する研究 : Toll-like receptorによるマスト細胞の活性化について"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:50:11.751397+00:00"}