{"created":"2023-06-19T07:19:09.652442+00:00","id":5072,"links":{},"metadata":{"_buckets":{"deposit":"9fd58d76-e9fe-4909-b9ef-a00339e34653"},"_deposit":{"created_by":4,"id":"5072","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"5072"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00005072","sets":["17:37:227","17:40:280","31:181:494"]},"author_link":["22032","22028","22033","22031","22029","22030"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"298","bibliographicPageStart":"295","bibliographicVolumeNumber":"15/16","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マスト細胞は,自然免疫および適応免疫において様々なメディーターを放出することにより細菌感染免疫応答関与している。PCB126のマスト細胞免疫応答に対する影響を調べるため,PCB126前処理マスト細胞におけるLPS刺激によるサイトカイン誘導能とその関連分子について検討した。LPS刺激によりマスト細胞は前炎症性サイトカイン,ケモカインの遺伝子および蛋白発現が上昇するが,PCB126で前処理されたマスト細胞ではその発現が阻害された。cq1はPCB126特異的にマスト細胞内で強く誘導された。cq1蛋白の作用綴字がNFkBを利用することから,PCB126によるLPS刺激後のマスト細胞サイトカイン産生抑制はNFk-Bにおける競合による可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Mast cell plays central regulators of innate and acquired immunities through production of various chemical mediators and cytokines. It has been mentioned that Co-PCB influence host immune systems, however the mechanism remains unclear. We have previously reported that LPS stimulates mast cells to produce various cytokines. In the present study, we have studied the effect of PCS 126 on LPS-mediated cytokine and chemokine production from mast cell. Administration of PCB126 reduced production of pro-inflammatory cytokines and chemokines. Interestingly, PCB126 specifically enhanced Cql mRNA expression which is regulated by NFkB signaling pathway. Pro-inflammatory cytokine and clq induction are mediated by the same NFkB signaling pathway, therefore the reduction of LPS-mediated cytokine production from mast cell pretreated with PCB126 might be competed NFkB signaling pathway.","subitem_description_type":"Other"}]},"item_12_description_18":{"attribute_name":"レポート・演題番号","attribute_value_mlt":[{"subitem_description":"麻布大学ハイテク・リサーチ・センター研究プロジェクト 研究サブ・グループ4","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561560","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000065"},{"subitem_text_value":"-"},{"subitem_text_value":"000259"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"School of Vetrinary Medicine, Azabu University"},{"subitem_text_value":"School of Vetrinary Medicine, Azabu University"},{"subitem_text_value":"School of Vetrinary Medicine, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000065"},{"subitem_text_value":"-"},{"subitem_text_value":"000259"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 輝雄"},{"creatorName":"イケダ, テルオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"舟場, 正幸"},{"creatorName":"フナバ, マサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村上, 賢"},{"creatorName":"ムラカミ, マサル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Teruo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Funaba, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2007-01-01"}],"displaytype":"detail","filename":"bull_jau_vol15-16-295.pdf","filesize":[{"value":"423.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol15-16-295.pdf","url":"https://az.repo.nii.ac.jp/record/5072/files/bull_jau_vol15-16-295.pdf"},"version_id":"e600a5dc-f634-4693-b5cb-9843dcca4998"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響"},{"subitem_title":"The effects of Co-PCB in allergic disorfer : Analyses of mast cell functions in response to Co-PCB(Research Group 4,Azabu University High-Tech Research Center Project : Study on the Biological Toxicity and Development of the Technology for the Environmental Monitoring and Remediation of Dioxins and -Related Compounds)","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["227","280","494"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-01-01"},"publish_date":"2007-01-01","publish_status":"0","recid":"5072","relation_version_is_last":true,"title":["マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:44:17.884125+00:00"}