@article{oai:az.repo.nii.ac.jp:00005053,
 author = {須永, 藤子 and 斉藤, 康秀 and 志村, 純子 and Sunaga, Fujiko and Saito, Yasuhide and Simura, Sumiko},
 journal = {麻布大学雑誌, Journal of Azabu University},
 month = {Mar},
 note = {900代培養原虫株は犬に対して病原性がなく免疫原性があり,B. gibsoni感染に対して強い発症防御効果があることが明らかとなった。, For trying to make live vaccine, the virulence of Oita isolate of Babesia gibsoni was attenuated by 900 passages in microaerophilus stationary phase (MASP) culture. Two dogs inoculated with the attenuated parasites did not elicit any clinical sign, but seroconverted. Two inoculated dogs were challenged with the virulent B. gibsoni isolate at the 60th day after inoculation. None of the inoculated dogs developed fever, but they showed low PCV depression and low parasitemia. The control dog challenged with the virulent isolate showed high fever (more than 40℃), severer PCV depression, and high parasitemia. These results suggested that the attenuated isolate was safety and effectivity as live vaccine., P(論文), 特集, application/pdf, FEATURE ARTICLES},
 pages = {212--213},
 title = {Babesia gibsoni症のワクチン開発},
 volume = {15/16},
 year = {2008},
 yomi = {スナガ, フジコ and サイトウ, ヤスヒデ and シムラ, スミコ}
}