{"created":"2023-06-19T07:19:08.623972+00:00","id":5048,"links":{},"metadata":{"_buckets":{"deposit":"a90576a5-5801-494d-8cde-ad1eca9009be"},"_deposit":{"created_by":4,"id":"5048","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"5048"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00005048","sets":["17:254:342","17:256:351","31:181:494"]},"author_link":["21899","21894","21897","21898","21895","21896"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"199","bibliographicPageStart":"198","bibliographicVolumeNumber":"15/16","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞へ栄養供給に役割をもつ輸送経路を特異的に阻害する化学物質であるBCHは,癌細胞への栄養供給輸送経路を阻害する。BCHを投与することで有意な制癌細胞が認めたBBN誘発ラット膀胱癌を対象として超微形態学的に検討した。BCH投与後ではアポトーシスを示す移行上皮癌細胞が認められたが,腫瘍細胞の壊死性変化は弱いものであった。これに対し,BCHは腫瘍組織内毛細血管検成細胞に対し比較的強い細胞毒性を示すことが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Previously, we observed that the amino-bicycloheptane-carboxylic acid (BCH) showed to inhibit the growth of N-butyl-N-(4-hydroxybutyl)nitrosamine induced rat bladder carcinoma, but the mechanisms of it was unclear. In the present study, we investigated the ulrastructural alterations of BBN induced rat baldder carcinomas following BCH injection. After treatement of BCH, apoptotic carcinoma cells were observed, and many microvascular endothelial cells showed alteration of structures. These results suggested that the BCH not only directly inhibited to survive the cancer cells, but also might be interfere with the flow of nutrients from microvasuclarture to the cancer cells.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561536","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000073"},{"subitem_text_value":"000068"},{"subitem_text_value":"-"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学大学院獣医学研究科"},{"subitem_text_value":"麻布大学大学院獣医学研究科"},{"subitem_text_value":"麻布大学大学院獣医学研究科"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Veterinary Science, Azabu University"},{"subitem_text_value":"Graduate School of Veterinary Science, Azabu University"},{"subitem_text_value":"Graduate School of Veterinary Science, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000073"},{"subitem_text_value":"000068"},{"subitem_text_value":"-"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和久井, 信"},{"creatorName":"ワクイ, シン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高木, 敬彦"},{"creatorName":"タカギ, ユキヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内藤, 博之"},{"creatorName":"ナイトウ, ヒロユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakui, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takagi, Yukihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naito, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2007-01-01"}],"displaytype":"detail","filename":"bull_jau_vol15-16-198.pdf","filesize":[{"value":"143.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol15-16-198.pdf","url":"https://az.repo.nii.ac.jp/record/5048/files/bull_jau_vol15-16-198.pdf"},"version_id":"547a207a-aa2d-4f60-af85-ce7cd299d0d0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"BCHの抗癌作用に関する実験病理学的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"BCHの抗癌作用に関する実験病理学的検討"},{"subitem_title":"Ulrastructural observation on BCH for BBN-induced rat bladder carcinoma","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["342","351","494"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-01-01"},"publish_date":"2007-01-01","publish_status":"0","recid":"5048","relation_version_is_last":true,"title":["BCHの抗癌作用に関する実験病理学的検討"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:43:28.657088+00:00"}