{"created":"2023-06-19T07:19:08.364639+00:00","id":5042,"links":{},"metadata":{"_buckets":{"deposit":"7b20b1a7-7475-4870-957d-94f2b0d0b3f7"},"_deposit":{"created_by":4,"id":"5042","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"5042"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00005042","sets":["17:236:244","17:251:307","17:254:334","17:38:261","17:40:290","31:181:494"]},"author_link":["21850","21860","21857","21861","21864","21846","21853","21851","21856","21855","21863","21845","21849","21858","21848","21847","21859","21854","21852","21862"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"177","bibliographicPageStart":"172","bibliographicVolumeNumber":"15/16","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では,犬の肝細胞癌株化細胞または正常肝細胞を用いHGFの細胞増殖に及ぼす影響について検討した。肝癌細胞株4種を用いて検討した結果,3様の反応が認められた。一定の濃度まで増殖が促進され,それ以上の濃度では増殖がプラトーに達する株(CHKS-rL),一定の濃度まで増殖が促進され,さらに濃度を増すと増殖が抑制される傾向を示す株(95-1044),HGFに反応が乏しく増殖促進,抑制の影響が明らかではない株(KO, 930-599A)に分類された。一方,正常犬肝細胞とHGFに増殖反応を示す肝癌細胞で,増殖を促進する濃度が類似しているため,HGFの利用は困難であり,HGFで増殖を示さない肝癌細胞(KO, 930-599A)で利用可能と考えられた。治療に際しHGFに対する反応を簡易に検出することが重要と考えられた。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"In this study, we examined the effects of feline recombinant HGF (frHGF) on proliferation of four types of canine hepatocellular carcinoma cells and normal canine hepatic cells in culture. Three types of responses were observed in the tumor cells. One was increased growth correlated with increasing HGF up to a certain concentration when a growth ceiling was reached (CHKS-rL cells). The second was growth correlated with increasing concentration of HGF, after which growth decreased gradually in inverse proportion to HGF concentration (95-1044 cells). The remaining two cell lines (KO, 930-599A) did not show a consistent reaction to HGF. Normal canine hepatic cells also proliferated at an HGF concentration close to that of CHKS-rL and 95-1044 cells. Thus, HGF for treatment of patients bearing tumors of CHKS-rL or 95-1044 cells will be ineffective; however, it is a useful treatment for patients with tumors of KO or 930-599A cells.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE 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University"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Laboratory of Hyginic Technology, College of Environmental Health, Azabu University"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Veterinary Teaching Hospital, Azabu University"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu 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