{"created":"2023-06-19T07:19:08.237167+00:00","id":5039,"links":{},"metadata":{"_buckets":{"deposit":"ee1494ef-9adf-4b14-8851-888a621a9e8f"},"_deposit":{"created_by":4,"id":"5039","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"5039"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00005039","sets":["17:253:319","17:257:356","17:36:211","31:181:494"]},"author_link":["21827","21828","21829","21825","21830","21826"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"163","bibliographicPageStart":"161","bibliographicVolumeNumber":"15/16","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"選択的COX-1阻害薬piroxicamと選択的COX-2阻害薬etodolacのラット胎子動脈管に及ぼす影響について検討した。Piroxicamおよびetodolacにおいて,用量依存的に胎子動脈管は収縮した。一方,免疫組織学的に,動脈管におけるCOX-1およびCOX-2の局在を検索してみたが,その局在を確認することができなかった。本研究では,動脈管におけるCOX-1およびCOX-2の局在を明らかにできなかったが,COX-1あるいはCOX-2のどちらかのCOXのアイソフォームが阻害されても胎子動脈管が収縮することが示され,これらの両方のアイソフォームがともに動脈管の調節に機能していることが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Constrictive effect of a selective cyclooxygenase (COX)-l inhibitor, piroxicam, and a selective COX-2 inhibitor, etdolac, on the ducts arteriosus (DA) was investigated in the rat. Rats were given piroxicam (10, 30, 100 mg/kg) or etodlac (10, 30, 100 mg/kg) on day 21 of pregnancy, and fetal ductus arteriosus (DA) was studied with a whole-body freezing method. All proxicam-treated groups and the 30 mg/kg and 100 mg/kg etodolac-treated groups showed a significant constriction of the DA 3 hours dose-dependently after maternal each COX inhibitor treatment. These results indicate that both COX-1 and COX-2 selective inhibitor induce constriction of the fetal DA in a dose-dependent manner as well as non-selective COX inhibitors when administered in late stage of gestation and that both COX-1 and COX-2 regulate doctus arteriosus tone in the fetal rat.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561527","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000047"},{"subitem_text_value":"000059"},{"subitem_text_value":"000230"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学大学院獣医学研究科"},{"subitem_text_value":"麻布大学大学院獣医学研究科"},{"subitem_text_value":"麻布大学大学院獣医学研究科"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Veterinary Science, Azabu University"},{"subitem_text_value":"Graduate School of Veterinary Science, Azabu University"},{"subitem_text_value":"Graduate School of Veterinary Science, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000047"},{"subitem_text_value":"000059"},{"subitem_text_value":"000230"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"有嶋, 和義"},{"creatorName":"アリシマ, カズヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 雅子"},{"creatorName":"ヤマモト, マサコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"白井, 明志"},{"creatorName":"シライ, ミツユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arishima, Kazuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Masako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirai, Mitsuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2007-01-01"}],"displaytype":"detail","filename":"bull_jau_vol15-16-161.pdf","filesize":[{"value":"245.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol15-16-161.pdf","url":"https://az.repo.nii.ac.jp/record/5039/files/bull_jau_vol15-16-161.pdf"},"version_id":"a9b5b73c-7d0f-450d-8ef2-2f19f271ef4e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット周生期における動脈管調節因子の発現動態とその機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット周生期における動脈管調節因子の発現動態とその機能"},{"subitem_title":"Characterization of regulators of ductus arteriosus tone in the perinatal rat","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["211","319","356","494"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-01-01"},"publish_date":"2007-01-01","publish_status":"0","recid":"5039","relation_version_is_last":true,"title":["ラット周生期における動脈管調節因子の発現動態とその機能"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:43:26.390302+00:00"}