{"created":"2023-06-19T07:19:08.017265+00:00","id":5034,"links":{},"metadata":{"_buckets":{"deposit":"e1cd8907-0860-499a-a773-9168198958c1"},"_deposit":{"created_by":4,"id":"5034","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"5034"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00005034","sets":["17:236:250","31:181:494"]},"author_link":["21802","21801"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"141","bibliographicPageStart":"138","bibliographicVolumeNumber":"15/16","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"野外株44株とF9,255,CFI株を含む計47株について50% plaque-depressing dose (PDD_<50>)によりrFeIFNに対する感受性を比較した。47株のPDD_<50>は101.1～103.7の範囲に正規分布していた。これらの平均値±標準偏差(2.3±0.64)の範囲に含まれるものを中感受性とし,それよりも低いものを低感受性,高いものを高感受性とし,各株の感受性を遺伝子群により比較すると,G Iは低感受性が16%(4/25),中感受性が68%(17/25),高感受性が16%(4/25)含まれ,G IIは低感受性が23%(5/22),中感受性が72%(16/22),高感受性が5%(1/22)含まれた。G IIの方に低感受性株が多く含まれる傾向が見られ,F9株が含まれるG Iのクラスター(C-7)に含まれる3/5(60%)株が高感受性株を示した。ワクチンブレイクダウン由来株は中感受性を示すものが多く,低感受性株が見られないことからブレイクにはrFeIFN感受性の関与は低いことが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"To examine the relationship between the FCV strains and rFeIFN sensitivity, the sensitivity of 47 field isolates to rFeIFN was determined. The PDD_<50> values were distributed within the range 10^<1.1>-10^<3.7>, with a mean value of 10^<2.3>±10^<0.64>. Since 68.3 % of the FDD values fell in the range of the mean ± standard deviation, the values in the range 10^<1.7>-10^<2.9>, the lower values, and the higher values were defined as representing moderate, low, and high sensitivity, respectively. Of the viruses belonging to C7 of G I, 3/5 (60 %) were highly sensitive, suggesting that rFeIFN is effective for them. Among the 15 vaccine breakdown strains, strain Fukuoka9 showed a low sensitivity, but strains ML89, T58, and N74 were highly sensitive, showing no association with vaccine breakdown. The amino acid sequence changes specific to the low rFeIFN-sensitive Fukuoka-9 strain were found, suggesting that these sites are involved in rFeIFN sensitivity.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561522","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000039"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部獣医学科微生物学科II研究室"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology II, School of Veterinary Medicine, Azabu Universitu"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000039"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原, 元宣"},{"creatorName":"ハラ, モトノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"21801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Motonobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21802","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2007-01-01"}],"displaytype":"detail","filename":"bull_jau_vol15-16-138.pdf","filesize":[{"value":"316.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol15-16-138.pdf","url":"https://az.repo.nii.ac.jp/record/5034/files/bull_jau_vol15-16-138.pdf"},"version_id":"10be7cbc-21cd-4216-bff8-c11aa151f96b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ネコカリシウイルス(FCV)の分子多様性に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ネコカリシウイルス(FCV)の分子多様性に関する研究"},{"subitem_title":"Study on the molecular variety of Feline calicivims (FCV) : Sensitivity to rFeIFN","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["250","494"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-01-01"},"publish_date":"2007-01-01","publish_status":"0","recid":"5034","relation_version_is_last":true,"title":["ネコカリシウイルス(FCV)の分子多様性に関する研究"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:44:37.919277+00:00"}