{"created":"2023-06-19T07:19:04.228346+00:00","id":4848,"links":{},"metadata":{"_buckets":{"deposit":"faec90de-b3a8-4e2d-85a2-8a48df0978ca"},"_deposit":{"created_by":4,"id":"4848","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4848"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004848","sets":["31:181:508"]},"author_link":["21117","21114","21113","21116","21112","21115"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"156","bibliographicPageStart":"150","bibliographicVolumeNumber":"11/12","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細菌感染におけるマスト細胞の役割はほとんど注目されていない。しかしながら,近年の多くの研究からマスト細胞が多様な腸内細菌による感染症に対する感染防御の重要な細胞であることが示されてきた。本研究ではマスト細胞欠損マウス(WBBF1-W/W^v)を用いて,細菌感染におけるマスト細胞感染防御能検討した。その結果,(1)マスト細胞はアドヒジョンタンパク質により活性化される。(2)細菌は活性化されたマスト細胞によって殺菌されること,(3)活性化されたマスト細胞はIL-3産生し,それがオートクラインによってマスト細胞数の増殖をもたらすことがわかった。これらのことから,細菌感染において,マスト細胞は重要な役割を果たしていることが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The role of mast cells in infections is invariably thought of as a detrimental one. However, recent studies have shown that mast cell play a key role in host defense against various enterobacterial infections. In this study, using mast cell-dificient and mast cell-sufficient mice we have investigated the protective role of mast cells in the infections. Our findings indicate that i. the mast cells are activated by adhesion protein, ii. Killing bacteria is dependent on the activated mast cells, and iii.activated mast cell secret IL-3 and the IL-3 promote mast cell proliferation by autocrine. Taken together, these findings suggest a beneficial role of mast cells in infections in mice.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部病態生化学研究室"},{"subitem_text_value":"麻布大学栄養学研究室"},{"subitem_text_value":"麻布大学分子生物学研究室"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Laboratory of Pathbiochemistory and Imunanuloguy, Azabu University"},{"subitem_text_value":"Laboratory of Nutrition, Azabu University"},{"subitem_text_value":"Laboratory of Molecular Biology, Azabu University"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 輝雄"},{"creatorName":"イケダ, テルオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"21112","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"舟場, 正幸"},{"creatorName":"フナバ, マサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"21113","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 賢"},{"creatorName":"ムラカミ, マサル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"21114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikeda, Teruo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Funaba, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21117","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2005-01-01"}],"displaytype":"detail","filename":"bull_jau_vol11-12-150.pdf","filesize":[{"value":"921.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol11-12-150.pdf","url":"https://az.repo.nii.ac.jp/record/4848/files/bull_jau_vol11-12-150.pdf"},"version_id":"33ddc207-4a53-45b6-9945-e61febe9be29"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"免疫応答におけるマスト細胞活性化機構に関する研究 : Toll-like receptorによるマスト細胞活性化について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫応答におけるマスト細胞活性化機構に関する研究 : Toll-like receptorによるマスト細胞活性化について"},{"subitem_title":"Activating mechamism of mast cell in immuno-responses : mast cell activation due to Toll-like receptor","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["508"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-01-01"},"publish_date":"2005-01-01","publish_status":"0","recid":"4848","relation_version_is_last":true,"title":["免疫応答におけるマスト細胞活性化機構に関する研究 : Toll-like receptorによるマスト細胞活性化について"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T08:00:42.792986+00:00"}