{"created":"2023-06-19T07:19:03.968370+00:00","id":4842,"links":{},"metadata":{"_buckets":{"deposit":"4290526c-2c4e-4d3c-bc73-6adb271d0e94"},"_deposit":{"created_by":4,"id":"4842","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4842"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004842","sets":["31:181:508"]},"author_link":["21062","21063"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"125","bibliographicPageStart":"123","bibliographicVolumeNumber":"11/12","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"FCV感染野外例において,3年(5回)に渡るウイルス分離により22株分離され,originをoutgroupとした分子系統樹により,1-3年目(3-5回目)の分離ウイルスが一つの明瞭なクラスターを形成した。1st isolatesの中和抗体価とアミノ酸配列の距離の相関関係では,originからのアミノ酸距離が遠くなるほど交差性が低くなることが示された。FCVは個体を通過するに従い,アミノ酸距離が遠くなり,それに伴い中和抗体に対する交差性も低下するようである。排泄期間とoriginとのアミノ酸距離の関係では,領域B,領域C,3'HVR of E,領域Fで高い負の相関が見られた。個体問伝播をする時にoriginとのアミノ酸距離が遠くなるほど排泄期間が短くなる傾向が見られた。逆に距離が近い株に感染した個体ほど排泄期間が長く持続する傾向があった。1年以降に分離されたウイルス(3rd, 4th, 5th isolates)はさらに変異が顕著となり,それ以前に分離されたウイルスと異なるクラスターを形成し,排泄期間の長い個体が見られた。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"To examine the mutations in the capsid region and antigenicity associated with FCV transmission and persistent infection in the field case, it was performed a phylogenetic analysis of a total of 22 strains : (6 strains isolated from 3-, 4-, and 5-month-old kittens that had been born in the same colony, and 2 strains isolated from 2 cats manifested latent infection (the first isolates), 14 strains isolated during three years post first isolation. The neutralizing antibody titers for the first isolates decreased with a high negative correlation with the distance between capsid protein genes (Y=-129.98X+15.09, r=-0.84). A high negative correlation was also found in the C and E regions. The neutralizing antibody titers of rabbit anti-F9 serum decreased with a high negative correlation with the genetic distance of the capsid region (Y=-26.64X+4.32, r=-0.90). A correlation was also observed in region C and the 5'HVR of regions E and F. The duration of virus secretion showed a high negative correlation with the distances between the origin and the amino acids in region B, region C, the 3'HVR of region E, and region F : the farther the distance between the origin and the amino acid became as a result of interindividual transmission, the shorter the duration of virus secretion. The slower the evolution of amino acids in persistently infected individual cats, the longer the duration of virus excretion, suggesting the involvement of region A.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部獣医学科微生物学教室II"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology II, School of Veterinary Medicine, Azabu University"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原, 元宣"},{"creatorName":"ハラ, モトノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"21062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Motonobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21063","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2005-01-01"}],"displaytype":"detail","filename":"bull_jau_vol11-12-123.pdf","filesize":[{"value":"288.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol11-12-123.pdf","url":"https://az.repo.nii.ac.jp/record/4842/files/bull_jau_vol11-12-123.pdf"},"version_id":"dc04ab3d-ad94-423c-9ada-bc78611bd69c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ネコカリシウイルス(FCV)の分子多様性に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ネコカリシウイルス(FCV)の分子多様性に関する研究"},{"subitem_title":"Study on the molecular variety of Feline calicivirus (FCV)","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["508"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-01-01"},"publish_date":"2005-01-01","publish_status":"0","recid":"4842","relation_version_is_last":true,"title":["ネコカリシウイルス(FCV)の分子多様性に関する研究"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T08:00:49.659507+00:00"}