{"created":"2023-06-19T07:19:03.882232+00:00","id":4840,"links":{},"metadata":{"_buckets":{"deposit":"a8217c65-07ce-477d-a1f6-85cba1ad7f67"},"_deposit":{"created_by":4,"id":"4840","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4840"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004840","sets":["31:181:508"]},"author_link":["21055","21053","21052","21051","21050","21054"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"113","bibliographicPageStart":"110","bibliographicVolumeNumber":"11/12","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"3週齢～35週齢のオスおよびメスのオズボーン・メンデル(OM)ラット129匹の腎臓について形態学的観察を行い,細胞浸潤や線維化といった尿細管・間質病変が,糸球体の分節性硬化や癒着といった上皮細胞障害に続発する非可逆的糸球体病変の進展に伴って,加齢と共に進行することを確認した。免疫組織学的観察から,オスでは5週齢より腎間質にTリンパ球が浸潤したが,B細胞やマクロファージは遅れて出現し,後者は特に少数であることが明らかになった。浸潤Tリンパ球の約半数はCD8陽性細胞であった。メスでは問質浸潤細胞のポピュレーションとその比率は同様であったが,問質病変はオスよりも軽度であった。また,ICAM-1,MCP-1分子およびその遺伝子の皮質における発現は,共に病変の進行につれ増加していた。免疫組織学的に,皮質におけるMMP-9の発現は減少し,その作用を阻害するTIMP-1のそれはむしろ増強する傾向が認められた。尿中には,TIMP-1やMCP-1などのケモカインが若齢時より検出されたが,加齢にともなう変化は血清のそれとほぼ同様のパターンを示した。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Histopathological examination on the kidneys of 129 Osborn-Mendel rats aged 3 to 35 weeks revealed that tubulo-interstitial lesions including cellular infiltration and fibrosis developed with age and were associated with irreversible glomerular lesions such as segmental sclerosis and capsular adhesion following podocyte injury. Inflammation was first initiated by T-lymphocyte infiltration at 5 weeks of age in male rats and was associated with infiltration of B-lymphocytes and macrophages later on. The macrophages were far less than lymphocytes among the infiltrating cells. A half of the infiltrating lymphocytes was CD8-positive ones. In female rats the population of the infiltrating cells was similar to that in male rats but the severity of the tubulo-interstitial lesions was less intense. The expression of genes and their products of ICAM-1 and MCP-1 in the renal cortex of male rats was increased with age. Immunohistochemistry showed that the expression of MMP-1 was decreased and that of its inhibitor, TIMP-1 was increased in the cortex with age. Urinary excretion of TIMP-1 and several chemokines such as MCP-1 was detected in the early age of male rats and their change in excretory amount with age was seemed to be in accordance with those in the serum.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学大学院獣医学研究科"},{"subitem_text_value":"麻布大学大学院獣医学研究科"},{"subitem_text_value":"麻布大学大学院獣医学研究科"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Graduate School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"Graduate School of Veterinary Medicine, Azabu University"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"代田, 欣二"},{"creatorName":"シロタ, キンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"21050","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"斑目, 広郎"},{"creatorName":"マダラメ, ヒロオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"21051","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 賢"},{"creatorName":"ムラカミ, マサル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"21052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shirota, Kinji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Madarame, Hiroo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21055","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2005-01-01"}],"displaytype":"detail","filename":"bull_jau_vol11-12-110.pdf","filesize":[{"value":"726.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol11-12-110.pdf","url":"https://az.repo.nii.ac.jp/record/4840/files/bull_jau_vol11-12-110.pdf"},"version_id":"2abdf3bb-1e10-4eed-a74c-07430bb27874"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"オズボーン・メンデルラットの進行性腎障害に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オズボーン・メンデルラットの進行性腎障害に関する研究"},{"subitem_title":"Study on the pathogenesis of progressive nephropathy in Osborn-Mendel rats","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["508"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-01-01"},"publish_date":"2005-01-01","publish_status":"0","recid":"4840","relation_version_is_last":true,"title":["オズボーン・メンデルラットの進行性腎障害に関する研究"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T08:00:52.893966+00:00"}