@article{oai:az.repo.nii.ac.jp:00004686,
 author = {松田, 基夫 and 岩橋, 和彦 and 信田, 卓男 and 小方, 宗次 and 吉原, 英児 and 荻原, 喜久美 and 陰山, 敏昭 and 柏崎, 直巳 and 村山, 洋 and 飴野, 清 and 高島, 明彦 and Matsuda, Motoo and Iwahashi, Kazuhiko and Shida, Takuo and Ogata, Munetsugu and Yoshiwara, Eiji and Ogiwara, Kikumi and Kageyama, Toshiaki and Kashiwazaki, Naomi and Murayama, Ohoshi and Ameno, Kiyoshi and Takashima, Akihiko},
 journal = {麻布大学雑誌, Journal of Azabu University},
 month = {Mar},
 note = {ヒトGSK3β遺伝子のプロモーター領域について多型解析を行った結果,統合失調症および躁鬱病と有意に相関する遺伝子多型は認められなかった。このことは,mRNAの安定性に関与する領域,トランス調節因子などについて解析する必要があることを示唆している。, The aim of this study is to reveal polymorphism in genes associated with psychiatric disorders and neurodegenerative diseases. Genomic DNA from patients affected by schizophrenia or bipolar, and normal humans were analyzed. Comparing the psychiatric disorders with normal humans, no significant differences in a ratio of polymorphism found throughout the regulatory region of GSK3β gene (promoter and 5'-UTR). Lithium, a therapeutic agent for psychiatric disorder such as bipolar, inhibits GSK3βand production of amyloidβ, a main component of senile plaques in Alzheimer's disease. In addition, the level of GSK3βis decreased in schizophrenia patients and increased depending on aging. The results in this study lead us to consider that 3'-UTR of GSK3β gene and trans acting factors for GSK3β transcription should be studied. In conclusion, the present data may provide us basic and important information that promote revealing the molecular mechanism for regulation of GSK3βgene expression., P(論文), 特集, application/pdf, FEATURE ARTICLES},
 pages = {229--231},
 title = {精神疾患関連遺伝子多型の解析},
 volume = {9/10},
 year = {2005},
 yomi = {マツダ, モトオ and イワハシ, カズヒコ and シダ, タクオ and オガタ, ムネツグ and ヨシワラ, エイジ and オギワラ, キクミ and カゲヤマ, トシアキ and カシワザキ, ナオミ and ムラヤマ, オホシ and アメノ, キヨシ and タカシマ, アキヒコ}
}