@article{oai:az.repo.nii.ac.jp:00004684,
 author = {原, 元宣 and 木内, 明男 and 福山, 正文 and Hara, Motomobu and Kiuchi, Akio and Fukuyama, Masafumi},
 journal = {麻布大学雑誌, Journal of Azabu University},
 month = {Mar},
 note = {一般的に雄は仔猫に興味を示すことはなく,仔猫の世話をするのは専ら雌猫であるが,今回は,雄成猫が感染源となり,仔猫へ感染するという結果となった。, A multicat household experienced an epidemic of feline calicivirus (FCV) infection. We analyzed molecular evolution of isolated FCVs by a phylogenic tree reconstructed around the genotype of FCV that was isolated from the cat of infectious origin. FCV was isolated from eight of 34 cats: two 1-year-old, male littermates that became latent carriers (Ao198-1 and Ao199-1); two 3-month-old littermates (Ao222-1 and Ao224-1); three 4-month-old littermates (Ao210-1, Ao212-1 and Ao213-1) and a 5-month old (Ao210-1). All the isolates belonged to the genogroup II, and their nucleotide sequences showed >94% homology. They were subdivided into six distinct clusters by phylogenetic analysis, and Ao198-1, the source of infection, was most closely related to Ao199-1, then Ao212-1, Ao210-1, Ao214-1, Ao213-1, Ao222-1and Ao224-1 in this order. The similar result was obtained by phylogenic analysis of amino acid sequences. Sequence alignments of the isolates showed that the nonsynonymous substitution/total number of nucleotides ratio was <40% in the regions A, B, D and F, and >60% in the regions C and E. The nucleotide substitution/total number of nucleotides ratio was 33%, 12% and 15.6% at the region C and two hypervariable regions (5'and 3'HVRs) of the region E, respectively, and less than 10% at the other regions. For amino acids, the ratio was 50%, 24%, 10.3% and 25% at 5' and 3'HVRs of the regions C and E, respectively, especially high at the 5'HVR of the region C. The other regions were less than 10%. Our result suggested that the virus, while its transmission to the newborn cats, underwent frequent mutation especially at the regions C and E, suggesting these regions were most often involved in evolution of the FCV genome., P(論文), 特集, application/pdf, FEATURE ARTICLES},
 pages = {215--220},
 title = {ネコカリシウイルス(FCV)の分子多様性に関する研究},
 volume = {9/10},
 year = {2005},
 yomi = {ハラ, モトモブ and キウチ, アキオ and フクヤマ, マサフミ}
}