{"created":"2023-06-19T07:19:00.906433+00:00","id":4681,"links":{},"metadata":{"_buckets":{"deposit":"cd5b5bed-a58c-45b9-987d-6bfcb510a61e"},"_deposit":{"created_by":4,"id":"4681","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4681"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004681","sets":["17:236:244","17:236:245","17:254:334","17:38:266","17:42:292","31:181:490"]},"author_link":["20375","20365","20367","20366","20372","20361","20377","20362","20370","20376","20378","20364","20371","20369","20373","20374","20368","20363"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"203","bibliographicPageStart":"198","bibliographicVolumeNumber":"9/10","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"c-Met proto oncogeneは肝細胞増殖因子(Hepatocyte growth factor: HGF)のレセプターであり,ヒト,マウスではあらゆる上皮,内皮系細胞での発現が認められている。HGF/c-Metシグナル伝達は,細胞の増殖,運動および形態形成などを誘導し,その機能的重要性が示唆されるが,本研究ではイヌのc-Met完全長cDNAのクローニングおよび組織分布の検討を行った。イヌc-Met cDNAのOpen reading frameは4419塩基,1383個のアミノ酸で構成され,さらにmRNAは,末梢血単核球,骨髄,肝臓,腎臓,肺,胃,子宮,精巣,胸腺,リンパ節,小腸,大腸,副腎,甲状腺心臓,筋肉,皮膚,膵臓,卵巣,前立腺,脾臓,脂肪,大脳,小脳組織での発現が確認された。一方,急性骨髄性白血病(1/1),慢性骨髄性白血病(2/2),骨髄異形生症候群(1/3)の犬の骨髄でC-Met mRNAの過剰な発現が認められたのに対しリンパ球性白血病および形質細胞腫の犬の骨髄での発現は正常組織と同程度であった。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The c-Met proto-oncogene is the receptor for hepatocyte growth factor (HGF), which is a member of the tyrosine kinase family. Activation of the HGF/c-Met signal pathway leads to cell proliferation, motility, and morphogenesis. In human and mouse, c-Met is detected in various epithelial and endothelial cells and numerous studies have indicated it to be an important component of cellular function. In this study, the complete sequence of complementary DNA (cDNA) of canine c-Met was cloned, and its distribution was determined in tissues. The canine c-Met cDNA clone had an open reading frame of 4419 bp which encoded a putative polypeptide of 1383 amino acids. Furthermore, it was indicated that c-Met was expressed in a variety of canine tissues including peripheral blood mononuclear cells (PBMC), bone marrow, liver, kidney, lung, stomach, uterus, testis, thymus, lymph node, small intestine, colon, adrenal grand, thyroid gland, heart, muscle, skin, pancreas, ovary, prostate, spleen, fat, cerebrum and cerebellum. The c-Met m-RNA was overexpressed in the bone marrow cells from acute myelocytic leukemia (1/1), chronic myelocytic leukemia (2/2) and myelodysplastic syndrome (1/3), however, the expression of m-RNA in the bone marrow of chronic lymphocytic leukemia and plasmacytoma was normal bone marrow level.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author 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of Animal Genetics and Breeding, School of Veterinary Medicine, Azabu university"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu university"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu university"},{"subitem_text_value":"Department of Environmental Chemistry, College of Environmental Health, Azabu university"},{"subitem_text_value":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Science, The University of Tokyo"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu university"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu university"},{"subitem_text_value":"Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Azabu 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宣男"},{"creatorName":"カンサク, ノリオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"古市, 満"},{"creatorName":"フルイチ, ミツル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡辺, 征"},{"creatorName":"ワタナベ, マサシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久松, 伸"},{"creatorName":"ヒサマツ, シン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻本, 元"},{"creatorName":"ツジモト, ハジメ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"久末, 正晴"},{"creatorName":"ヒサスエ, マサハル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土屋, 亮"},{"creatorName":"ツチヤ, リョウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 隆紹"},{"creatorName":"ヤマダ, タカツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NEO, Sakurako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KANSAKU, Norio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FURUICH, Mitsuru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WATANABE, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HISAMATSU, Sin","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUJIMOTO, Hajime","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HISASUE, Masaharu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUCHIYA, Ryo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMADA, 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