{"created":"2023-06-19T07:19:00.776435+00:00","id":4678,"links":{},"metadata":{"_buckets":{"deposit":"13bc1ef6-22e6-4dee-b353-26db64bd17d9"},"_deposit":{"created_by":4,"id":"4678","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4678"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004678","sets":["17:254:334","31:181:490"]},"author_link":["20346","20345"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"190","bibliographicPageStart":"188","bibliographicVolumeNumber":"9/10","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年,免疫介在性溶血性貧血,血小板減少症,あるいは骨髄線維症などの免疫介在疾患の犬に対して,ヒトの免疫グロブリン(h-IVIG)療法が用いられるようになっている。この治療法の主な副作用として,血栓症の発現が危惧されているが,それについての詳細な検討は行われていない。そこで我々は,実験的にIVIGを投与した犬の凝固系検査と血小板凝集試験を実施して,本療法による血栓症発現リスクについて検討した。2頭のビーグル犬にヒトIgG製剤を1g/kg静脈内投与した。その結果,2頭に共通して,末梢血の白血球数と血小板数は投与開始2～4時間後に減少し,その後も数日間持続した。フィブリン/フィリノーゲン分解産物も,IVIG投与開始8時間後から24時間後にかけて増加した。また,1頭において顕著なフィブリノーゲン濃度の増加が認められた。さらに血小板凝集試験の結果,ADP刺激ではIVIG投与開始2時間後から24時間後にかけて,またPAF刺激では投与開始2時間後に,顕著な凝集活性の低下が認められた。以上の結果から,IVIG療法による血栓症発現のリスクは,予想以上に高いものと思われた。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Intravenous human immunoglobulin (h-IVIG) therapy is currently used for dogs with immunemediated diseases including hemolytic anemia, thrombocytopenia and bone marrow fibrosis. The most important potential adverse effect of this therapy is thromboembolism; however, this risk has not previously been evaluated in dogs. Therefore, we experimentally investigated changes of the complete blood cell counts, coagulation parameters and platelet aggregation in dogs that were administered h-IVIG. Human immunoglobulin G 1g/kg was infused intravenously for 8 hours in two dogs. Leukopenia and thrombocytopenia occurred in both the dogs 2-4 hours after starting the infusion and these changes persisted for several days. Fibrin/fibrinogen degradation products were increased 8 and 24 hours after starting the infusion. Plasma fibrinogen concentration increased in one of the dogs given h-IVIG. ADP-induced platelet aggregation was decreased 2 to 24 hours after starting the infusion compared to baseline studies. PAF-induced aggregation was also decreased relative to baseline 2 hours after staring the infusion. These results suggest a much higher risk of embolism than had been expected.","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000071"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"School of Veterinary Medicine, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000071"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土屋, 亮"},{"creatorName":"ツチヤ, リョウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchiya, Ryo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2004-01-01"}],"displaytype":"detail","filename":"bull_jau_vol9-10-188.pdf","filesize":[{"value":"239.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol9-10-188.pdf","url":"https://az.repo.nii.ac.jp/record/4678/files/bull_jau_vol9-10-188.pdf"},"version_id":"b5f9c97b-8d1f-4cc5-9689-3d783d4e7fc2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"イヌの免疫介在性血小板減少症に対するIgG大量静注(IVIG)療法の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"イヌの免疫介在性血小板減少症に対するIgG大量静注(IVIG)療法の検討"},{"subitem_title":"Study of intravenous IgG therapy for dogs with immune-mediated thrombocytopenia","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["334","490"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-01-01"},"publish_date":"2004-01-01","publish_status":"0","recid":"4678","relation_version_is_last":true,"title":["イヌの免疫介在性血小板減少症に対するIgG大量静注(IVIG)療法の検討"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:48:17.546094+00:00"}