{"created":"2023-06-19T07:18:50.833127+00:00","id":4458,"links":{},"metadata":{"_buckets":{"deposit":"94f91066-0322-4024-86f0-50cf5ad2a213"},"_deposit":{"created_by":4,"id":"4458","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4458"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004458","sets":["17:256:351","31:181:487"]},"author_link":["19531","19532"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"216","bibliographicPageStart":"215","bibliographicVolumeNumber":"5/6","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"比較的低用量3,3',4,4',5-pentachlorobiphenyl(PCB126)胎生期暴露で7,12-dimethlvenz(a)anthracene(DMBA)誘発乳腺発癌が亢進するのに対し,高用量PCB126胎生期暴露では発癌が抑制させることを報告した。本検討ではDMBA投与時(生後50日齢)のラット乳腺の発達について検討した。250ng投与群では他の群と比較して有意なterminal end buds(TEB)の増数,さらにalveolar buds and lobules(ABL)の減数が認められた。これに対し,7.5ug投与診では他の群と比較して有意なTEB,ABLの減数が認められた。比較的低用量PCB126投与群で特にTEBの増数が認められたことが,問診でのDMBA誘発乳腺発癌の亢進と関係することが示唆された。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Recently we reported finding that prenatal exposure to relatively low dose 3,3',4,4',5- pentachlorobiphenl (PCB126) acts as an enhancing agent toward 7, 12-dimethlbenz (a) anthracene (DMBA) -induced rat mammary carcinomas, while high dose acts as an inhibiting agent for them. One of the most important factors determining sensitivity of the mammary gland to neoplastic stimuli is its stage of differentiation at the time of exposure to the carcinogenic agent. Hence, to verify a biphasic dose-response relationship (enhancement of carcinogenesis at low, and inhibition at high dose), we investigated the effects of prenatal exposure to PCB126 on mammary gland differentiation. Female SD rats were injected (i. G.) with 25 pg, 2.5 ng, 250 ng, 7.5μg of PCB126/kg, or the vehicle, on days 13 to 19 post-conception. 50-day-old female offspring of the 250ng-group showed apparent inhibition of the normal differentiation of terminal end buds (TEB) to alvolar buds and lobules (ABL), while those of the 7.5μg-group showed mammary glands hypoplasia. In the developing mammary gland, TEBs have been considered as the most susceptible to mammary carcinogenesis, while ABLs as relatively protected against mammary carcinogenesis. Thus, prenatal exposure to relative low dose PCB126 induced an alteration of mammary gland differentiation that might potentially increase a risk of DMBA-induced mammary carcinomas.","subitem_description_type":"Other"}]},"item_12_description_18":{"attribute_name":"レポート・演題番号","attribute_value_mlt":[{"subitem_description":"麻布大学ハイテク・リサーチ・センター研究プロジェクト 研究サブ・グループ6","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000073"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"School of Veterinary Medicine, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000073"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和久井, 信"}],"nameIdentifiers":[{"nameIdentifier":"19531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakui, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19532","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2002-01-01"}],"displaytype":"detail","filename":"bull_jau_vol5-6-215.pdf","filesize":[{"value":"138.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol5-6-215.pdf","url":"https://az.repo.nii.ac.jp/record/4458/files/bull_jau_vol5-6-215.pdf"},"version_id":"c8174be0-1a0d-42c6-bb9a-83088fedbab1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ダイオキシン類の発癌性への影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ダイオキシン類の発癌性への影響"},{"subitem_title":"Effects of Exposure to Dioxins, as Endocrine Disruptors, on Carcinogenesis.","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["351","487"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-01-01"},"publish_date":"2002-01-01","publish_status":"0","recid":"4458","relation_version_is_last":true,"title":["ダイオキシン類の発癌性への影響"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:47:39.161201+00:00"}