{"created":"2023-06-19T07:18:50.789172+00:00","id":4457,"links":{},"metadata":{"_buckets":{"deposit":"a20a7b4d-3470-461a-8795-c6b680cfafbb"},"_deposit":{"created_by":4,"id":"4457","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4457"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004457","sets":["17:37:227","31:181:487"]},"author_link":["19528","19527","19529","19530"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"214","bibliographicPageStart":"213","bibliographicVolumeNumber":"5/6","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マスト細胞におけるAhRシグナリング関連分子のmRNAの発現とCo-PCBsの影響を検討した。マスト細胞株のうちRBL-2H3とIC-2,初代培養マスト細胞(BMCMCs)がAhRとARNTのmRNAを発現していた。またレポーターアッセイのレシピエントとしてよく知られているRaw294およびCHO-K1はいずれのmRNAも発現していなかった。陽性対照として使用したTCDDおよびCo-PCBsのいずれの濃度でもマスト細胞の脱顆粒およびTNF-αの放出に影響しなかった。これらの結果は,マスト細胞がCo-PCBsのターゲット細胞ではあるが,脱顆粒およびTNF-αの放出が介在した免疫反応には直接影響しないことを示唆している。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"In this study, we examined the gene expression of molecules involved in AhR signaling and the effects of Co-PCBs in mast cell. The niRNA expression of AhR and ARNT was detected in RBL-2H3, IC-2 and Bone marrow derived cultured mast cell (BMCMCs). Raw 294 and CHO-K1 known as recipient cell in reporter assay, were not expressed both mRNAs. Any concentrations of Co-PCBs and TCDD as control did not affected degranulation and TNF-a release in both of RBL-2H3 and BMCMCs. These results suggest that mast cells are the targets of Co-PCBs, but Co-PCBs does not involved directly immune-response through both degranulation and TNA-a release in mast cells.","subitem_description_type":"Other"}]},"item_12_description_18":{"attribute_name":"レポート・演題番号","attribute_value_mlt":[{"subitem_description":"麻布大学ハイテク・リサーチ・センター研究プロジェクト 研究サブ・グループ5","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE ARTICLES","subitem_description_type":"Other"}]},"item_12_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"麻布大学"}]},"item_12_publisher_20":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Azabu University"}]},"item_12_source_id_21":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-5880","subitem_source_identifier_type":"ISSN"}]},"item_12_source_id_23":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11561468","subitem_source_identifier_type":"NCID"}]},"item_12_text_10":{"attribute_name":"Author ID","attribute_value_mlt":[{"subitem_text_value":"000065"},{"subitem_text_value":"-"}]},"item_12_text_11":{"attribute_name":"所属機関","attribute_value_mlt":[{"subitem_text_value":"麻布大学獣医学部"},{"subitem_text_value":"麻布大学獣医学部"}]},"item_12_text_12":{"attribute_name":"Institution or Company","attribute_value_mlt":[{"subitem_text_value":"School of Veterinary Medicine, Azabu University"},{"subitem_text_value":"School of Veterinary Medicine, Azabu University"}]},"item_12_text_9":{"attribute_name":"著者ID","attribute_value_mlt":[{"subitem_text_value":"000065"},{"subitem_text_value":"-"}]},"item_12_version_type_29":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_12_version_type_30":{"attribute_name":"text version","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 輝雄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"舟場, 正幸"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Teruo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Funaba, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2002-01-01"}],"displaytype":"detail","filename":"bull_jau_vol5-6-213.pdf","filesize":[{"value":"100.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bull_jau_vol5-6-213.pdf","url":"https://az.repo.nii.ac.jp/record/4457/files/bull_jau_vol5-6-213.pdf"},"version_id":"872b1e1f-76f2-4927-bdd4-7e698254ac14"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響"},{"subitem_title":"The effects of Co-PCBs in allergic disorder : Analyses of mast cell functions in response to Co-PCBs.(Research Group 5)","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["227","487"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-01-01"},"publish_date":"2002-01-01","publish_status":"0","recid":"4457","relation_version_is_last":true,"title":["マスト細胞活性化機構の解析を中心としたアレルギー疾患に及ぼすコプラナーPCBsの影響"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:51:15.508475+00:00"}