{"created":"2023-06-19T07:18:50.660354+00:00","id":4454,"links":{},"metadata":{"_buckets":{"deposit":"6e3afc3d-8cd8-468f-94a6-fdba0a6864c0"},"_deposit":{"created_by":4,"id":"4454","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4454"},"status":"published"},"_oai":{"id":"oai:az.repo.nii.ac.jp:00004454","sets":["17:251:307","17:251:309","31:181:487"]},"author_link":["19520","19519","19518","19517","19514","19522","19515","19513","19516","19521"],"item_12_biblio_info_16":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"208","bibliographicPageStart":"207","bibliographicVolumeNumber":"5/6","bibliographic_titles":[{"bibliographic_title":"麻布大学雑誌"},{"bibliographic_title":"Journal of Azabu University","bibliographic_titleLang":"en"}]}]},"item_12_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"野生型およびHis^<61>をPheもしくはSerに置換したP-糖タンパク質(PGP)を発現したLLC-PK1を作出した。これらのPGP発現細胞のvinblastineおよびcolchicine耐性は増強し,細胞内幕積は減少していた。PCB-126はフィルター上に培養したPGP発現細胞でvinblastineの経上皮細胞層輸送を阻害した。","subitem_description_type":"Abstract"}]},"item_12_description_14":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"The LLC-PK1 cells expressing wild type P-glycoprotein (POP) and mutant POP in which His^<61> was substituted with Phe or Ser were prepared. In these POP expressing cells, tolerances to vinblastine and colchicine were increased, and accumulations of these drugs were reduced. PCB-126 inhibited transepithelial transport of vinblastine in these PGP expressing cells on the bottom filtered well.","subitem_description_type":"Other"}]},"item_12_description_18":{"attribute_name":"レポート・演題番号","attribute_value_mlt":[{"subitem_description":"麻布大学ハイテク・リサーチ・センター研究プロジェクト  研究サブ・グループ2","subitem_description_type":"Other"}]},"item_12_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_12_description_3":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_description":"特集","subitem_description_type":"Other"}]},"item_12_description_34":{"attribute_name":"format","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"Type","attribute_value_mlt":[{"subitem_description":"FEATURE 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protein.","subitem_title_language":"en"}]},"item_type_id":"12","owner":"4","path":["307","309","487"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-01-01"},"publish_date":"2002-01-01","publish_status":"0","recid":"4454","relation_version_is_last":true,"title":["コプラナーPCBsによるABCタンパク質機能阻害がxenobioticsの細胞毒性およびステロイドホルモン代謝に与える影響"],"weko_creator_id":"4","weko_shared_id":4},"updated":"2023-06-19T07:49:35.593806+00:00"}